Patho-Infectious Flashcards
Warthin-Finkeldey Cells
- multinucleated giant cells
- eosinophilic nuclear and cytoplasmic inclusions
MEASLES
Organs affected by MUMPS
CNS, Parotid, Testes
-with mononuclear infiltrates
Cowdry Type A
-pink to purple intranuclear inclusion bodies
HSV
Dewdrops on Rose Petal
-intraepithelial vesicles
VZV
Owl’s eye
- intranuclear, basophilic with clear halo
- large cells with ATYPIA
CMV
-heterophile negative
Transforming virus
-paracortical hyperplasia
EBV
- heterophile positive
- causes mononucleosis
Causes
- granulomatosis infatiseptica
- chorioamnionitia
Listeria monocytogenes
-Gram + bacilli
Fleur-de-list pattern
- pale necrotic centers
- red, hemorrhagic periphery
Pseudomonas
- perivascular blue haze
- coagulative necrosis
Donovan bodies
-Giemsa/Warthin-Starry stain
Klebsiella granulomatis
-granuloma inguinale
IL-12 -> APC -> TH1 -> macrophage, granuloma, caseation necrosis
Depressed CMI: accumulation of AFB
PTB
1 Ghon focus, Ghon complex (LN involvement)
2 Simmon focus
Pulmonary progressive (involvement of vasculature)
3 Miliary pulmonary
Intact CMI Lepromin + TH1 Asymmetric peripheral nerve involvement Granulomatous
Tuberculoid
-paucibacillary
Depressed CMI Lepromin - TH2 Antibodies cause GN (type 3 hypersensitivity) Lipid- laden macrophages
Lepromatous
- multibacillary
- Lepra cells
1 Chancre
2 Mucocutaneous
3 Neurosyphilis, gummas, aortitis
Treponema pallidum
Congenital Syphilis Triad
Interstitial keratitis
Hutchinsons teeth
Eight nerve deafness
Gas gangrene
Clostridium perfringes
- alpha toxin
- lecithinase
Mucopurulent exudate reminiscent of a volcano
Clostricium difficile
L Strains (Lymphogranuloma venereum)
Chlamydia trachomatis
Thrush
Candida albicans
-pseudohyphae
Mucicarmine +
Soap bubble lesion in CNS in immunocompromised, granulomatous in immunocompetent
Cryptococcus neoformans
Septate hyphae
Acute
Aspergillus
Nonseptate hyphae
Right angle
Mucor
Parasite with hemozoin
Plasmodium
- in asexual stage
- Malaria
Parasite without hemozoin
With MALTESE CROSS pattern
Babesia
-Babesiosis
Visceral: Kala-azar (hyperpigmentation)
Cutaneous: granulomatous
Diffuse cutaneous: foamy macrophage
Leishmaniasis
Affects heart and ganglion
Causes dilated cardiomyopathy
Megacolon
Megaesophagus
Trypanosomiasis
American
- T. Cruzi
Demyelinating panencephalitis (leptomeningitis)
Hemolymphatic spread
African
T. bruceii
Penetration to skin > lungs > GIT
Autoinfection in GIT
Strongyloides stercoralis
-nematode
Encyst muscles with richest blood supply
“Nurse Cells” in skeletal muscles
Trichinosis
-nematode
Lymphedema
Elephantiasis
Filiariasis
-nematode
With Meyers-Kouwenaar bodies
- dead worms surrounded by hyaline, eosinophili precipitates
Affects skin and eye
Skin: leopard or lizard or elephant skin; subcutaneous nodule
Eye: Mazzotti reaction, iridocyclitis and glaucoma, atrophy and loss of vision
Onchocerca volvulus
-nematode
Infective stage: cercaria
Eggs > bowel and bladder wall
Schistosoma japonicum and mansoni
-pipestem fibrosis (bowel)
Schistosoma heamatobium
- bladder wall
- granulomatous cystitis
- inc. Risk of bladder squamous cell CA
Hydatid disease
-carefully removed by surgeon to avoid rupture
Echinococcus granulosus
-cestode
Pathologic lesion: Cystecerci
With scolex
Taenia solium
-cestodes
