Patho-Infectious Flashcards
Warthin-Finkeldey Cells
- multinucleated giant cells
- eosinophilic nuclear and cytoplasmic inclusions
MEASLES
Organs affected by MUMPS
CNS, Parotid, Testes
-with mononuclear infiltrates
Cowdry Type A
-pink to purple intranuclear inclusion bodies
HSV
Dewdrops on Rose Petal
-intraepithelial vesicles
VZV
Owl’s eye
- intranuclear, basophilic with clear halo
- large cells with ATYPIA
CMV
-heterophile negative
Transforming virus
-paracortical hyperplasia
EBV
- heterophile positive
- causes mononucleosis
Causes
- granulomatosis infatiseptica
- chorioamnionitia
Listeria monocytogenes
-Gram + bacilli
Fleur-de-list pattern
- pale necrotic centers
- red, hemorrhagic periphery
Pseudomonas
- perivascular blue haze
- coagulative necrosis
Donovan bodies
-Giemsa/Warthin-Starry stain
Klebsiella granulomatis
-granuloma inguinale
IL-12 -> APC -> TH1 -> macrophage, granuloma, caseation necrosis
Depressed CMI: accumulation of AFB
PTB
1 Ghon focus, Ghon complex (LN involvement)
2 Simmon focus
Pulmonary progressive (involvement of vasculature)
3 Miliary pulmonary
Intact CMI Lepromin + TH1 Asymmetric peripheral nerve involvement Granulomatous
Tuberculoid
-paucibacillary
Depressed CMI Lepromin - TH2 Antibodies cause GN (type 3 hypersensitivity) Lipid- laden macrophages
Lepromatous
- multibacillary
- Lepra cells
1 Chancre
2 Mucocutaneous
3 Neurosyphilis, gummas, aortitis
Treponema pallidum
Congenital Syphilis Triad
Interstitial keratitis
Hutchinsons teeth
Eight nerve deafness
Gas gangrene
Clostridium perfringes
- alpha toxin
- lecithinase