Patho-Infectious Flashcards

1
Q

Warthin-Finkeldey Cells

  • multinucleated giant cells
  • eosinophilic nuclear and cytoplasmic inclusions
A

MEASLES

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2
Q

Organs affected by MUMPS

A

CNS, Parotid, Testes

-with mononuclear infiltrates

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3
Q

Cowdry Type A

-pink to purple intranuclear inclusion bodies

A

HSV

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4
Q

Dewdrops on Rose Petal

-intraepithelial vesicles

A

VZV

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5
Q

Owl’s eye

  • intranuclear, basophilic with clear halo
  • large cells with ATYPIA
A

CMV

-heterophile negative

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6
Q

Transforming virus

-paracortical hyperplasia

A

EBV

  • heterophile positive
  • causes mononucleosis
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7
Q

Causes

  • granulomatosis infatiseptica
  • chorioamnionitia
A

Listeria monocytogenes

-Gram + bacilli

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8
Q

Fleur-de-list pattern

  • pale necrotic centers
  • red, hemorrhagic periphery
A

Pseudomonas

  • perivascular blue haze
  • coagulative necrosis
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9
Q

Donovan bodies

-Giemsa/Warthin-Starry stain

A

Klebsiella granulomatis

-granuloma inguinale

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10
Q

IL-12 -> APC -> TH1 -> macrophage, granuloma, caseation necrosis

Depressed CMI: accumulation of AFB

A

PTB

1 Ghon focus, Ghon complex (LN involvement)
2 Simmon focus
Pulmonary progressive (involvement of vasculature)
3 Miliary pulmonary

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11
Q
Intact CMI
Lepromin +
TH1
Asymmetric peripheral nerve involvement
Granulomatous
A

Tuberculoid

-paucibacillary

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12
Q
Depressed CMI
Lepromin -
TH2
Antibodies cause GN (type 3 hypersensitivity)
Lipid- laden macrophages
A

Lepromatous

  • multibacillary
  • Lepra cells
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13
Q

1 Chancre
2 Mucocutaneous
3 Neurosyphilis, gummas, aortitis

A

Treponema pallidum

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14
Q

Congenital Syphilis Triad

A

Interstitial keratitis
Hutchinsons teeth
Eight nerve deafness

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15
Q

Gas gangrene

A

Clostridium perfringes

  • alpha toxin
  • lecithinase
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16
Q

Mucopurulent exudate reminiscent of a volcano

A

Clostricium difficile

17
Q

L Strains (Lymphogranuloma venereum)

A

Chlamydia trachomatis

18
Q

Thrush

A

Candida albicans

-pseudohyphae

19
Q

Mucicarmine +

Soap bubble lesion in CNS in immunocompromised, granulomatous in immunocompetent

A

Cryptococcus neoformans

20
Q

Septate hyphae

Acute

A

Aspergillus

21
Q

Nonseptate hyphae

Right angle

A

Mucor

22
Q

Parasite with hemozoin

A

Plasmodium

  • in asexual stage
  • Malaria
23
Q

Parasite without hemozoin

With MALTESE CROSS pattern

A

Babesia

-Babesiosis

24
Q

Visceral: Kala-azar (hyperpigmentation)
Cutaneous: granulomatous
Diffuse cutaneous: foamy macrophage

A

Leishmaniasis

25
Q

Affects heart and ganglion
Causes dilated cardiomyopathy
Megacolon
Megaesophagus

A

Trypanosomiasis
American
- T. Cruzi

26
Q

Demyelinating panencephalitis (leptomeningitis)

Hemolymphatic spread

A

African

T. bruceii

27
Q

Penetration to skin > lungs > GIT

Autoinfection in GIT

A

Strongyloides stercoralis

-nematode

28
Q

Encyst muscles with richest blood supply

“Nurse Cells” in skeletal muscles

A

Trichinosis

-nematode

29
Q

Lymphedema

Elephantiasis

A

Filiariasis
-nematode

With Meyers-Kouwenaar bodies
- dead worms surrounded by hyaline, eosinophili precipitates

30
Q

Affects skin and eye

Skin: leopard or lizard or elephant skin; subcutaneous nodule

Eye: Mazzotti reaction, iridocyclitis and glaucoma, atrophy and loss of vision

A

Onchocerca volvulus

-nematode

31
Q

Infective stage: cercaria

Eggs > bowel and bladder wall

A

Schistosoma japonicum and mansoni
-pipestem fibrosis (bowel)

Schistosoma heamatobium

  • bladder wall
  • granulomatous cystitis
  • inc. Risk of bladder squamous cell CA
32
Q

Hydatid disease

-carefully removed by surgeon to avoid rupture

A

Echinococcus granulosus

-cestode

33
Q

Pathologic lesion: Cystecerci

With scolex

A

Taenia solium

-cestodes