Patho Exam 1: REV Flashcards
Acidosis/Alkalosis
ROME
-
Respirotaroy Opposite
- pH up PCO2 down= Alkalosis
- pH down PCO2 up= Acidosis
-
Metabolic Equal
- pH up HCO3 up = Alkalosis
- pH down HCO3 down = Acidosis
Hypothalamus Functions
TAN HATS
- Thirst & Water balance
- Adenohypophysis
- Neurohypophysis
- Hunger & Satiety
- Autonomic regulation
- Temperature Reg
- Sexual urges & emotions
Causes/ R/T of Hyperkalemia
MACHINE
- Meds
- Acidosis
- Cellular destruction
- Hypoaldosteronism (hemolysis)
- Intake, excessive
- Nephrons, renal failure
- Excretion, impaired
Signs (AEB) Hyperkalemia
MURDER
- Muscle weakness
- Urine, oliguria, anuria
- Respiratory distress
- Decreased cardiac contractility
- EKG Changes, Peaked T Waves
- Reflexes, hyper, or hypo
Signs (AEB) Hypokalemia
6L’s
- Lethargy
- Lethat cardiac arrhthymia
- Leg cramps
- Limp Muscles
- Low, shallow respirations
- Less stool (constipation)
R/T Hypokalemia
GRAPHIC IDEA
- GI losses
- Renal
- Aldosterone
- PEriodic paralysis
- Insulin Excess
- Cushing;s Syndrome
- Insufficient intake
- Diuretics
- Elevated beta adrenergic activity
- Alkalosis
Signs (AEB) of Hypernatremia
FRIED
- Fever
- Restless
- Increase BP
- Edema
- Decreased Urinary Output
How much of the body fluid is intracellular
2/3
How much of the bod fluid is extracellular
1/3
What are the 2 components of extracellular compartment?
- interstitial
- intravascular
How does water move across membranes
freely
What is the major ECF cation
Sodium
What is the major ICF cation
potassium
a hormone that is secreted when sodium levels are depressed.
aldosterone
This hormone gets secreted when potassium is increased
adosterone
this is a result of an underlying disorder
hyperchloremia (elevated serum chlorine),
What is the usual cause of hyperchloremia
an increase in sodium and a deficit of bicarbonate
Are there symptoms of hyperchloremia
no
This is an outcome of serious burns, vomiting, or diarrhea
hypornatremia
When does hyperkalemia often occur
acidosis
This often occurs w/ acidosis. Hydrogen is taken up in the cell. It is exchanged for potassium and serum potassium rises.
Hyperkalemia
What would aldosterone cause for your potassium levels
hypokalemia
A patient has deep and rapid respirations. Laboratory tests reveal decreased pH and bicarbonate. This patient is experiencing:
metabolic acidosis
A common cause of the increased filtration of fluid from capillaries and lymph into surrounding tissues (edema) includes:
- inc hydrostatic pressure
- dec plasma oncotic pressure.
- inc capillary membrane permeability.
- lymphatic obstruction
What is the process called where carbon dioxide (CO2) is exchanged for oxygen?
Respiration
This is the mechanical movement of gas or air into and out of the lungs
Ventilation
This is actual blood flow and oxygen delivery.
Circulation
Which muscles has a major role in respiration?
- External intercostal
- Diaphragm
characterized by a slightly increased ventilatory rate, very large tidal volumes, and no expiratory pause
Kussmaul respiration (hyperpnea)
This iss the selective bulbous enlargement of the end of a digit (finger or toe). It is commonly associated with diseases that cause chronic hypoxemia, such as bronchiectasis, cystic fibrosis, pulmonary fibrosis, lung abscess, and congenital heart disease
clubbing
Conditions that can cause of hypercapnia? x4
- Disease of the medulla
- Large airway obstruction
- Thoracic cage abnormalities
- Depression of the respiratory center
hypocapnia characteristics
- severe anxiety
- Results in respiratory alkalosis
- PaCO2 less than 36 mm Hg
RUB MUB
Respiratory Uses Bicarb
Metabolic Uses Breathing
When your acid bases are fully compensated, what is normal
pH
When your acid bases are partially compensated
pH will still be off balance, but something is still trying to correct it
Who is Sodium’s buddy
Chloride
Who pares with Calcium but is always inversed
phosphate
This is in both intercellular space and extracellular
Bicarb
Phosphate
ICF includes
- Potassium
- Magnesuium
ECF includes:
- Sodium
- Chloride
- Calcium
- Phosphate
Calcium Normal Value
8.5-10.5
Potassium Normal Value
3.5-5
Sodium Normal Value
135-145
Chloride Normal Value
95-105
Magnesium Normal Value
1.5-2.0
Phosphate Normal Value
1.6-2.6
Why does sodium interact with calcium?
to maintain muscle contraction
Signs of Hyponatremia
SALT LOSS
- Stupor/Coma
- Anorexia
- Lethargy
- Tendon Reflexes Decreased
- Limp Muscles
- Orthostatic Hypotenion
- Seizures/headaches
- Stomach Cramping
Signs of HypoCalcemia
CATS
- Convulsions
- Arrhythmias
- Tetany
- Spasma/Stridor
Hypernatremia Etiology
MODEL
- Medications/Meals
- Osmotic Diuretics
- Diabetes Insipidus
- Excessive Water Loss
- Low Water Intake
a condition marked by intermittent muscular spasms, caused by malfunction of the parathyroid glands and a consequent deficiency of calcium.
Tetany
intravascular water is
blood
Children vs Adult Water Retention
- 70% kids
- 45% older adults
- prone to dehydration
What are non electrolytes
- most organic molecules
- do not dissociate in water
- carry NO net electrical charge
- (example: protein, glucose)
What are electrolytes
- dissociate in water to ions
- inorganic salts, acids, bases, some bases
- more osmotic pwr (attract water)
Functions of electroylyes
- regulate nerve/muscle function
- hemodynamically stable
- stay hydrated
- manage pH
- blood pressure
- damaged tissue repair
relating to the flow of blood within the organs and tissues of the body
hemodynamic
How do we maintain homeostasis
- movement of fluids & electrolytes
- fluid intake and fluid output
- hormonal regulation
- adh, Adosterone, Renin, Angiotensin, Natriuretic Peptides
What changes the hydrostatic pressure
force of the weight of water molecules pressing against the confining walls.
What are the results of hydrostatic pressure
- movement from an area of Greater pressure to lower pressure
- makes cell wall more permeable
Exerted by proteins, notably albumin, in a blood vessel’s plasma (blood/liquid) that usually tends to pull water into the circulatory system.
- Oncotic pressure
- (egg white, dense less permeable)
- keep fluid in
fluid getting backed up in the tissue
edema
hydrostatic pressure=
osmotic/oncotic pressure (not inflamed)
3 Classification of Osmolarity
- isotonic (same as blood)
- hypotonic (water, more inside)
- hypertonic (gatorade, more outside)
Normal serum osmolarity
280-295 mOsm/L
What directions to solutes diffuse?
high to low
What direction does osmosis move?
towards higher concentration
Moves both water and small solutes from high pressure to low pressure
Filtration
What are 7 mechanisms for fluid balance
- hypothalamic,
- pituitary
- Adrenal cortex (on top of kidneys)
- Kidneys
- Heart
- GI Tract
- Insensible water loss
These hormones regulate body fluid x4
- Renin Angiotensin
- Aldosterone
- Natriuretic Peptides
- Antidiuretic hormone (keep water)
RAAS stimulates
- Angiotensinogen* (renin)> Angiotensin I (enzyme) > Angiotenin II > potent vasoconstrictor, stimulates aldosterone secretion
ex: ace inhibitor (decreases BP), low sodium
hormones secreted by your heart in response to BP and blood volume that stretch heart tissues
NP- Natriuretic Peptides
When does ADH respond
- to serum osmolaltiy,
- fever,
- pain,
- stress,
- opiods
- (LOW BLOOD VOLUME)
It is better to be lacking fluid than
osmolarity
With a decrease in ADH release, urine will be more
dilute
Types of fluid volume imbalances
- deficit
- excess
- shift
- ECF it is accompanied by changes in the serum sodium levels
What is 3rd spacing
- constantly leaking out
- not easily exchanged with ECF
Cations have a positive or negative charge?
positive
What is the major cation in the blood
Sodium (Na+)
extracellular
What regulates potassium
- aldosterone.
- Increase aldosterone increase excretion of potassium
- everytime you pee lose potassium
- Na+ & K go opposite one another
Hypoxia Signs & Symptoms
RAT BED
Early Signs:
- Restlessness
- Anxiety
- Tachycardia/Tachypnea
Late Signs:
- Bradycardia
- Extreme Restlessness
- Dyspnea
the patient who is vomiting will lose a significant amount of gastric acid and be at an increased risk for
metabolic alkalosis
gastric secretions are rich in
hydrochloric acid
You are caring for a patient admitted with a diagnosis of chronic obstructive pulmonary disease (COPD) who has the following arterial blood gas results: pH 7.33, PaO2 47 mm Hg, PaCO2 60 mm Hg, HCO3 32 mEq/L, and O2 saturation of 92%. What is the correct interpretation of these results?
Partially compensated respiratory acidosis
You are caring for a patient receiving calcium carbonate for the treatment of osteopenia. Which serum laboratory result would you identify as an adverse effect related to this therapy?
Phosphorus falling to 2.1 mg/dL
contraindicated during episodes of hypokalemia because these medications cause the kidneys to excrete sodium and potassium
Loop Diuretics
Which nursing intervention is most appropriate when caring for a patient with dehydration?
Monitor daily weight and intake and output.
When planning care for a patient with dehydration related to nausea and vomiting, the nurse would anticipate which fluid shift to occur because of the fluid volume deficit?
Fluid movement from the interstitial space into the blood vessels
Magnesium food containing products
- chocolate
- nuts
- peanut butter
- banana
Used to remove excess magnesium in the blood
renal dialysis
The patient is admitted with metabolic acidosis. Which system is not functioning normally?
Kidney
The dehydrated patient is receiving a hypertonic solution. What assessments must be done to avoid risk factors of these solutions
- Lung sounds
- Blood Pressure
- Serum sodium level
What is a compensatory mechanism for metabolic acidosis
hyperventilation (allow to continue)
During sepsis, the formation of lactic acid is common during this process?
metabolic acidosis
Recspiratory acidosis Examples:
- hypoventilation, increase PCO2
- Compensation: Kidneys Reabsorb Bicarb
Metabolic Acidosis Examples
- Lactic Acidosis
- Renal Failure
- Ketones
- Ammonium intoxication
- Compensation: Hyperventilation to eliminate CO2
How does Respiratory alkalosis compensate?
Kidneys excrete HCO3
Causes for Metabolic Alkalosis
- Emesis
- diuretics
- retention of HCO3 medication,
- Hyperaldosteronism
How does the body compensate for metabolic alkalosis?
- Respiratory cts not stimulated
- Hypoventilation
- CO2 retention
Respiratory Acidosis Retains
Bicarb
Metabolic Acidosis Increases
Ventilation
Hyperventilating decrease PC02 causing what to happen to pH
Rise (respiratory alkalosis)
Normal Value for PCO2
35-45
Normal Value for HCO3
22-26
Normal Value for PO2
80-100
Base Excess: -2 - +2
- Always negative w/ metabolic acidosis
- awalys positive w/ metabolic alkalosis
Nursing Interventions for Metabolic Alkalosis
- monitor ABG levels
- monitor hypokalemia
- monitor hypocalcemia
- I/Os
Risk Factors Metabolic Acidosis
- hyperchloremia
- lactic acidosis
- renal failure
- severe diarhea
How close should intake an output be
roughly equal (2000 mL/day)
this is required for blood clotting
calcium
a protein whose presence in the blood promotes aldosterone secretion and tends to raise blood pressure.
Angiotensin