Patho Flashcards
Neurotransmitters
Acetylcholine Histamine GABA Oxytocin Vasopressin Monoamines: dopamine, seratonin, epinephrine, norepinephrine
Where is the “gate” located
Dorsal horn of the spinal cord
Transduction
activation of nociceptors - how it starts
Transmission
Conduction to dorsal horn and up spinal cord
Perception
Process of receiving information once it hits the brain
Sensory/discriminative system
motivational/affective system
cognitive evaluative system
Modulation
Adaptation to pain
Excitatory neuromodulation in CNS and PNS
Substance P
Glutamate
Somatostatin
Inhibitory neuromodulation
GABA glycine serotonin norepinephrine endorphine
What triggers neuromodulators?
endorphins
Perceptual dominance
Pain at one location may cause an ↑ in the threshold in another location
Acute somatic pain
Arises from connective tissue, muscle, bone, and skin
A delta fibers: pain is sharp and well localized
C Fibers: dull ache
Acute visceral pain
Pain in internal organs and abdomen
Poorly localized as a result of ↓ nociceptors
Referred pain
Pain that is present in an area removed from its point of origin
Neuropathic pain
result of trauma or disease of nerves
Most often chronic
Peripheral: painful diabetic neuropathy
Central: phantom limb
Major sleep center in the body?
Hypothalamus
How much time does a person spend in REM
20-25%
4 classifications of sleep disorders
Dyssomnias*
Parasomnias*
Secondary sleep disorders
Sleep provoked disorders
Parasomnias
Somnambulism (sleep walking) Night terrors Restless leg syndrome Eating (sleep eating) Violent behaviors Assoc. with medical/psychiatric disorders Proposed sleep disorder
Sleep provoked disorders
Sleep stage alterations produced in certain disease states
Dyssomnias
Insomnia
Obstructive sleep apnea
primary and secondary hypersomnia (excessive sleeping)
Disorders of sleep/wake cycle (jet lag)
Age related changes to sleep: Elderly
Total sleep is ↓
Take longer to fall asleep
Awaken more frequently
Amount of time in stave IV sleep is ↓