Path VI Flashcards
type of microbe is salmonella
gram - bacilli
salmonella typhi causes what
thyphoid fever
when is peak incidenc of salmonella enteritis
summer and fall
contaminated foot like meat, poultry, eggs, milk
virulence factors salmonella
type III secretion system allow growth in phagosomes flagellin activate TLR5 prevent TLR4 activation attracts neutrophils
what immune response activates in salmonella
Th17
Sx salmnoella
fever, pain, diarrhea or dysentery
how does salmonella affect peyers patches
in terminal ileum to enlarge into plateau like elevations
neutrophils accumulate
mucosal shedding creates oval ulcers oriented along axis of ileum that may perforate
liver in typhoid fecter
typhoid nodules- amcrophage aggregates
clinical features typhoid fever
anorexia, abdominal pain, bloating, nausea, vomiting bloody diarrhea, flu like Sx from bacteremia
maculopapular lesions
result of cholera toxin
decrease in NaCl resorption
Cl HCO3 secretion
most comon bacterial enteritis in world
campylobacter enterocolitis
transmission campylobacter enterocolitis
chicken, milk, water
Sx campylobacter
flu like prodrome
arthritis, IBS
erythema nodosum
what cells take up shigella
M cells, Left colon
What is pseudomembranous colitis
adherent layer of inflammatory cells and debris over sites of mucosal injury
toxins from C difficile
A and B
Dx C difficile
detecting cytotoxin in stool
Whipple disease
chronic relapsing multisystem illness of GI tract, diarrhea, steatorrhea, malabsorption
Sx whipple disease
weight loss, diarrhea, polyarthritis
what cause whipple
tropheryma whipplei
whipple disease affects?
Whites 4-th-5th decades 10:1 male predominance
Tx whipple disease
antibiotics
source cryptosporidium spp
contaminated water
where does cryptosporidium spp concentrate
terminal ileum and right colon
diarrhea causing agents that affect AIDS
cryotosporidum, atypical mycobacteria, CMV
what parasites cause enterocolitis
nematodes, cestodes, trematodes, unicellular parasites
where to you transmit entamoeba histolytica
mature cysts in fecally contaminated food water or on hands
msot common pathogenic parasitic infection
giardia
3 clinical forms giardia
asymptomatic carrier w/ w/o Hx clinical disease
acute diarrhea
chronic GI disease with malabsopriong, recurrent diarrhea, with or w/o abdominal discomfort
where does giardia occur
child day care centers
developing countries
