Path VI

Question 1

type of microbe is salmonella

Answer 1

gram - bacilli

Question 2

salmonella typhi causes what

Answer 2

thyphoid fever

Question 3

when is peak incidenc of salmonella enteritis

Answer 3

summer and fall

contaminated foot like meat, poultry, eggs, milk

Question 4

virulence factors salmonella

Answer 4

type III secretion system
allow growth in phagosomes
flagellin
activate TLR5
prevent TLR4 activation
attracts neutrophils

Question 5

what immune response activates in salmonella

Answer 5

Th17

Question 6

Sx salmnoella

Answer 6

fever, pain, diarrhea or dysentery

Question 7

how does salmonella affect peyers patches

Answer 7

in terminal ileum to enlarge into plateau like elevations
neutrophils accumulate
mucosal shedding creates oval ulcers oriented along axis of ileum that may perforate

Question 8

liver in typhoid fecter

Answer 8

typhoid nodules- amcrophage aggregates

Question 9

clinical features typhoid fever

Answer 9

anorexia, abdominal pain, bloating, nausea, vomiting bloody diarrhea, flu like Sx from bacteremia
maculopapular lesions

Question 10

result of cholera toxin

Answer 10

decrease in NaCl resorption

Cl HCO3 secretion

Question 11

most comon bacterial enteritis in world

Answer 11

campylobacter enterocolitis

Question 12

transmission campylobacter enterocolitis

Answer 12

chicken, milk, water

Question 13

Sx campylobacter

Answer 13

flu like prodrome
arthritis, IBS
erythema nodosum

Question 14

what cells take up shigella

Answer 14

M cells, Left colon

Question 15

What is pseudomembranous colitis

Answer 15

adherent layer of inflammatory cells and debris over sites of mucosal injury

Question 16

toxins from C difficile

Answer 16

A and B

Question 17

Dx C difficile

Answer 17

detecting cytotoxin in stool

Question 18

Whipple disease

Answer 18

chronic relapsing multisystem illness of GI tract, diarrhea, steatorrhea, malabsorption

Question 19

Sx whipple disease

Answer 19

weight loss, diarrhea, polyarthritis

Question 20

what cause whipple

Answer 20

tropheryma whipplei

Question 21

whipple disease affects?

Answer 21

Whites 4-th-5th decades 10:1 male predominance

Question 22

Tx whipple disease

Answer 22

antibiotics

Question 23

source cryptosporidium spp

Answer 23

contaminated water

Question 24

where does cryptosporidium spp concentrate

Answer 24

terminal ileum and right colon

Question 25

diarrhea causing agents that affect AIDS

Answer 25

cryotosporidum, atypical mycobacteria, CMV

Question 26

what parasites cause enterocolitis

Answer 26

nematodes, cestodes, trematodes, unicellular parasites

Question 27

where to you transmit entamoeba histolytica

Answer 27

mature cysts in fecally contaminated food water or on hands

Question 28

msot common pathogenic parasitic infection

Answer 28

giardia

Question 29

3 clinical forms giardia

Answer 29

asymptomatic carrier w/ w/o Hx clinical disease
acute diarrhea
chronic GI disease with malabsopriong, recurrent diarrhea, with or w/o abdominal discomfort

Question 30

where does giardia occur

Answer 30

child day care centers

developing countries