Hepatitis Tx II Flashcards

1
Q

MOA ribavirin

A

inhibits initiation/elongation RNA causing inhibition viral protein synthesis

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2
Q

adverse effects ribavirin

A

dose dependent hemolytic anemia, depression, fatigue, nausea, rash, insomnia
teratogenic, embryotoxic, oncogenic and maybe gonadotoxic

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3
Q

Therapeutic use ribavirin

A

chronic HCV in combo with peginterferon alfa and sofosbuvir

Influenza A B and RSV, paramyxoviruses and HIV-1

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4
Q

contraindications to ribavirin

A

anemia, end stage renal failure, ischemic vascular disease, pregnancy (and partners)

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5
Q

MOA sofosbuvir

A

direct acting antiviral, inhibits HCV NS5B RNA dependent RNA polymerase and is chain terminator

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6
Q

adverse effects sofosbuvir

A

fatigue, HA, insomnia, pruritis, nausea, diarrhea, flu-like Sx, anemia, neutropenia, weakness and myalgia

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7
Q

therapeutic use sofosbuvir

A

HCV

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8
Q

limit of sofosbuvir

A

cost! super duper stupid expensive. fuck pharmaceuticals

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9
Q

MOA simeprevir

A

direct acting antiviral, inhibits HCV NS3/4A protease which is needed for viral replication

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10
Q

how is simeprevir metabolized

A

CYP3A4

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11
Q

adverse effects simeprevir

A

skin rash, pruritis, nausea, increased serum bilirubin, myalgia

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12
Q

therapeutic use simprevir

A

HCV

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13
Q

drug interactions simeprevir

A

CYP inducers like rifampin will dec the simeprevir levels

may increase statins

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14
Q

limit of simeprevir

A

again. fuck pharmaceutical companies

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15
Q

what drugs are no longer recommended for HCV

A

boceprevir and telaprevir, the protease inhibitors

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16
Q

what do you add to regimen for HCV

A

ribavirin on top of the peginterferon

17
Q

Tx for HCV type I

A

IFN eligible: peg+ribavirin + SOF

IFN ineligible: SOF+ SMV and +/- ribavirin

18
Q

Tx HCV type II

A

SOF+ribavirin

19
Q

Tx HCV type III

A

SOF and ribavirin

20
Q

q80k polymorphism

A

need to rule out in patients that are genotype I HCV because change Tx options