Choudhury III Flashcards
what are the cells in the pancreas
ductal and acinar cells
describe acinar and ductal secretions from pancreas
acinar are enzyme rich
ductal are HCO3 rich and neutralized acidic chyme
chyme entering duodenuma causes what
duodenal enterendocrin cells to release CCK and secretin
What is role of CCK
induces secretion of enzyme rich pancreatic juice
causes gall bladder to contract and hepatopancreatic sphincter to relax so bile enters duodenum
reduced emptying in stomach
role of secretin
secretion of HCO3 rich pancreatic juice
during what phases does the vagus nerve cause gall bladder to contract
cephalic and gastric
What does enteropeptidase activate
trypsinogen to trypsin
what does trypsin activate
chymotrypsinogen to chymotrypsins proelastase to elastase procarboxypeptidase A to carboxypeptidase A and proc B to cB also activates PLA2
what protects pancreas from prematurely activated enzymes
protease inhibitors that are within the zymogen granules
What controls CCK release?
CCK-releasing peptide and monitor peptide
what cell release CCK
I cells
what inhibits CCK release
trypsin
what releases secretin
S cells in duodenal mucosa
at high rates of secretion what is content of pancreatic secretions
much more Cl andHCO3
not Na and H
(alkaline)
When pH falls in duodenum what is response
S cells secrete secretin