Path slides

Question 1

normal or abnormal?

Answer 1

normal bone marrow biopsy

Question 2

Answer 2

aplastic anemia

Question 3

Answer 3

BONE MARROW BIOPSY WITH METASTATIC CANCER

Question 4

describe the RBCs here

Answer 4

normocytic, have a zone of central pallor about 1/3 the size of the RBC. They have minimal variation in size (anisocytosis) and shape (poikilocytosis). A few small blue platelets are seen.

Question 5

what cell is pointed out here? is it normal or abnormal?

Answer 5

A normal mature lymphocyte is seen. An RBC is seen to be about 2/3 the size of the nucleus of a small lymphocyte.

Question 6

Answer 6

Increased reticulocytes /polychromatophils

Question 7

Answer 7

ringed sideroblast, abnormal. Found in lead & zinc poisoning, ethanol toxicity, INH treatment, copper or pyridoxine deficiency, MDS

Question 8

normal or abnormal neutrophil?

Answer 8

normal

Question 9

normal or abnormal neutrophil?

Answer 9

abnormal. hypersegmented

Question 10

what type of anemia

Answer 10

iron deficiency anemia (microcytic, hypochromic)

Question 11

with increased fragility of RBCs, defect in erythrocyte cytoskeleton. what’s the disease?

Answer 11

hereditary spherocytosis

Question 12

normocytic anemia, abnormal polymerization of spectrin. what’s the dx?

Answer 12

hereditary elliptocytosis

Question 13

diagnosis?

Answer 13

beta thalassemia

Question 14

nucleated RBCs occur in which disease?

Answer 14

hemolytic disease of newborn/erythroblastosis fetalis

Question 15

diagnosis?

Answer 15

sickle cell disease

Question 16

what type of RBCs? in what disease?

Answer 16

spur cells. in acanthocytosis (assoc with liver disease)

Question 17

(hairy cell leukemia/multiple myeloma/myelodysplastic syndrome/polycythemia vera/promyelocytic leukemia)

Answer 17

myelodysplastic syndrome (ringed sideroblasts)

Question 18

numerous oval macrocytes and hypersegmented neutrophils in an alcoholic

Answer 18

folic acid deficiency

Question 19

t(9;22)

Answer 19

chronic myelogenous leukemia

Question 20

smudge cells found in: (ALL/CLL/CML/multiple myeloma/Waldenstrom macroglobulinemia). picture shows more than 80% of WBCs are small lymphocytes.

Answer 20

chronic lymphocytic leukemia

Question 21

stained for TdT

Answer 21

acute lymphoblastic leukemia

Question 22

Reed Sternberg cell diagnostic hallmark of:

Answer 22

Hodgkin Lymphoma

Question 23

what’s shown in this bone marrow biopsy

Answer 23

myelofibrosis

Question 24

proliferation (in B cell areas/of dendritic cells/of plasma cells/in T cell areas/of marginal zone lymphocytes)

Answer 24

B cell areas. follicular hyperplasia

Question 25

cervical lymph node cells express surface IgM and are posiive for common B cell antigens. diagnosis?

Answer 25

Burkitt lymphoma

Question 26

cold agglutinins. diagnosis?

Answer 26

autoimmune hemolytic anemia

Question 27

fever, thrombocytopenia, microangiopathic hemolytic anemia, renal impairment, neuro symptoms

Answer 27

thrombotic thrombocytopenic purpura

Question 28

increased megakaryocytes with absent fibrosis

Answer 28

essential thrombocythemia

Question 29

what's the translocation associated with abnormal transformation of a pluripotent bone marrow cell resulting in prominent neutrophilic leukocytosis

Answer 29

t(9;22) philadelphia. CML

Question 30

normal lymphocytes. neoplasm of epithelial cells. what is it?

Answer 30

thymoma

Question 31

Wickham striae found in

Answer 31

lichen planus

Question 32

absent keratohyaline granules in epidermis, autosomal dominant

Answer 32

Ichthyosis vulgaris

Question 33

what type of melanoma

Answer 33

lentigo maligna melanoma

Question 34

desmoglein targeted by IgG

Answer 34

pemphigus vulgaris

Question 35

verruca vulgaris caused by which virus?

Answer 35

HPV

Question 36

IgG antibodies directed against basement membrane proteins BPAG1 and BPAG2

Answer 36

bullous pemphigoid (mnemonic: BPAG=bullous pemphigoid antigen)

Question 37

CD4+ lymphocytes in the epidermis

Answer 37

mycosis fungiodes

Question 38

palpable purpura

Answer 38

cutaneous necrotizing vasculitis aka allergic cutaneous vasculitis

Question 39

soap bubble appearance, Bence Jones proteins in urine

Answer 39

multiple myeloma

Question 40

punched out lytic lesions

Answer 40

multiple myeloma

Question 41

Birbeck granules (tennis racket appearance) found in

Answer 41

Langerhans cell histiocytosis

Question 42

atypical lymphocytes found in

Answer 42

mononucleosis

Question 43

What is the histological finding? the diagnosis?

Answer 43

clubbed epidermal projections that interdigitate with dermis Dx: psoriasis