Path slides Flashcards
normal or abnormal?
normal bone marrow biopsy
aplastic anemia
BONE MARROW BIOPSY WITH METASTATIC CANCER
describe the RBCs here
normocytic, have a zone of central pallor about 1/3 the size of the RBC. They have minimal variation in size (anisocytosis) and shape (poikilocytosis). A few small blue platelets are seen.
what cell is pointed out here? is it normal or abnormal?
A normal mature lymphocyte is seen. An RBC is seen to be about 2/3 the size of the nucleus of a small lymphocyte.
Increased reticulocytes /polychromatophils
ringed sideroblast, abnormal. Found in lead & zinc poisoning, ethanol toxicity, INH treatment, copper or pyridoxine deficiency, MDS
normal or abnormal neutrophil?
normal
normal or abnormal neutrophil?
abnormal. hypersegmented
what type of anemia
iron deficiency anemia (microcytic, hypochromic)
with increased fragility of RBCs, defect in erythrocyte cytoskeleton. what’s the disease?
hereditary spherocytosis
normocytic anemia, abnormal polymerization of spectrin. what’s the dx?
hereditary elliptocytosis
diagnosis?
beta thalassemia
nucleated RBCs occur in which disease?
hemolytic disease of newborn/erythroblastosis fetalis
diagnosis?
sickle cell disease
what type of RBCs? in what disease?
spur cells. in acanthocytosis (assoc with liver disease)
(hairy cell leukemia/multiple myeloma/myelodysplastic syndrome/polycythemia vera/promyelocytic leukemia)
myelodysplastic syndrome (ringed sideroblasts)
numerous oval macrocytes and hypersegmented neutrophils in an alcoholic
folic acid deficiency
t(9;22)
chronic myelogenous leukemia
smudge cells found in: (ALL/CLL/CML/multiple myeloma/Waldenstrom macroglobulinemia). picture shows more than 80% of WBCs are small lymphocytes.
chronic lymphocytic leukemia
stained for TdT
acute lymphoblastic leukemia
Reed Sternberg cell diagnostic hallmark of:
Hodgkin Lymphoma
what’s shown in this bone marrow biopsy
myelofibrosis
proliferation (in B cell areas/of dendritic cells/of plasma cells/in T cell areas/of marginal zone lymphocytes)
B cell areas. follicular hyperplasia
cervical lymph node cells express surface IgM and are posiive for common B cell antigens. diagnosis?
Burkitt lymphoma
cold agglutinins. diagnosis?
autoimmune hemolytic anemia
fever, thrombocytopenia, microangiopathic hemolytic anemia, renal impairment, neuro symptoms
thrombotic thrombocytopenic purpura
increased megakaryocytes with absent fibrosis
essential thrombocythemia
what’s the translocation associated with abnormal transformation of a pluripotent bone marrow cell resulting in prominent neutrophilic leukocytosis
t(9;22) philadelphia. CML
normal lymphocytes. neoplasm of epithelial cells. what is it?
thymoma
Wickham striae found in
lichen planus
absent keratohyaline granules in epidermis, autosomal dominant
Ichthyosis vulgaris
what type of melanoma
lentigo maligna melanoma
desmoglein targeted by IgG
pemphigus vulgaris
verruca vulgaris caused by which virus?
HPV
IgG antibodies directed against basement membrane proteins BPAG1 and BPAG2
bullous pemphigoid (mnemonic: BPAG=bullous pemphigoid antigen)
CD4+ lymphocytes in the epidermis
mycosis fungiodes
palpable purpura
cutaneous necrotizing vasculitis aka allergic cutaneous vasculitis
soap bubble appearance, Bence Jones proteins in urine
multiple myeloma
punched out lytic lesions
multiple myeloma
Birbeck granules (tennis racket appearance) found in
Langerhans cell histiocytosis
atypical lymphocytes found in
mononucleosis
What is the histological finding?
the diagnosis?
clubbed epidermal projections that interdigitate with dermis
Dx: psoriasis
