Path - Neoplasia (Psamomma bodies, Cancer epideimology, & Common metastases)

Question 1

What are 4 words to describe the appearance of psammoma bodies on histology?

Answer 1

Laminated, concentric, calcified spherules

Question 2

What are 4 conditions in which psammoma bodies are seen?

Answer 2

PSaMMoma bodies are seen in: (1) Papillary carcinoma of thyroid (2) Serous papillary cystadenocarcinoma of ovary (3) Meningioma (4) Malignant mesothelioma

Question 3

What 3 cancers have the highest incidence in males? What is the incidence of each?

Answer 3

(1) Prostate (32%) (2) Lung (16%) (3) Colon/rectum (12%)

Question 4

What 3 cancers have the highest incidence in females? What is the incidence of each?

Answer 4

(1) Breast (32%) (2) Lung (13%) (3) Colon/rectum (13%)

Question 5

How has lung cancer incidence changed in males versus females?

Answer 5

Lung cancer incidence has dropped in men, but has not changed significantly in women

Question 6

What 2 cancers have the highest mortality in males? What is the mortality of each?

Answer 6

(1) Lung (33%) (2) Prostate (13%)

Question 7

What 2 cancers have the highest mortality in females? What is the mortality of each?

Answer 7

(1) Lung (23%) (2) Breast (18%)

Question 8

What is the leading cause of death in the United States? What is the second?

Answer 8

Cancer is the 2nd leading cause of death in the United States (heart disease is 1st)

Question 9

What are 6 primary tumors that metastasize to the brain? List them in order of most to least likely to metastasize to brain.

Answer 9

(1) Lung > (2) Breast > (3) Genitourinary > (4) Osteosarcoma > (5) Melanoma > (6) GI

Question 10

What are 3 primary tumors that metastasize to the liver? List them in order of most to least likely to metastasize to brain, noting where there is a large discrepancy is likelihood.

Answer 10

(1) Colon&raquo_space; (2) Stomach > (3) Pancreas

Question 11

What are 4 primary tumors that metastasize to the bone? List them in order of most to least likely to metastasize to brain.

Answer 11

(1) Prostate, (2) Breast > (3) Lung > (4) Thyroid

Question 12

What percentage of brain tumors are from metastases?

Answer 12

50% of brain tumors are from metastases

Question 13

How do brain metastases commonly appear?

Answer 13

Commonly seen as multiple well-circumscribed tumors at gray/white matter junction

Question 14

What are the 2 most common sites of metastasis after the regional lymph nodes?

Answer 14

Liver and lung are the most common sites of metastasis after the regional lymph nodes

Question 15

Compare/Contrast bone metastasis and primary bone tumors in terms of likelihood.

Answer 15

Bone metastasis&raquo_space; Primary bone tumors (e.g., multiple myeloma, lytic)

Question 16

Give 2 examples of primary bone tumors.

Answer 16

Primary bone tumors (e.g., multiple myeloma, lytic)

Question 17

What is used to show spread of cancer to bones?

Answer 17

Whole-body bone scan shows tumor predilection for axial skeleton

Question 18

What type of bone metastases occur due to prostate versus breast primary tumors?

Answer 18

Prostate = blastic; Breast = lytic and blastic