Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

FA - Pathology > Path - Neoplasia (Oncogenes & Tumor suppressor genes) > Flashcards

Path - Neoplasia (Oncogenes & Tumor suppressor genes) Flashcards

Pg. 232 in First Aid 2014 Sections include: -Oncogenes -Tumor suppressor genes

1
Q

What change to oncogenes increase cancer risk? How many alleles must be affected to cause this?

A

Gain of function => increase cancer risk. Need damage to only 1 allele

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What tumors are associated with BCR-ABL gene?

A

CML, ALL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What type of gene is BCR-ABL? What is its gene product?

A

Oncogene; Tyrosine kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What tumors are associated with bcl-2 gene?

A

Follicular and undifferentiated lymphomas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What type of gene is bcl-2? What is its gene product?

A

Oncogene; Anti-apoptotic molecule (inhibits apoptosis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What tumor is associated with BRAF gene?

A

Melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What type of gene is BRAF? What is its gene product?

A

Oncogene; Serine/Threonine kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What tumor is associated with c-kit gene?

A

Gastrointestinal stromal tumor (GIST)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What type of gene is c-kit? What is its gene product?

A

Oncogene; Cytokine receptor (for stem cell factor)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What tumor is associated with c-myc gene?

A

Burkitt lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What type of gene is c-myc? What is its gene product?

A

Oncogene; Transcription factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What 3 tumors are associated with HER2/neu (c-erbB2) gene?

A

Breast, ovarian, and gastric carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What type of gene is HER2/neu (c-erbB2)? What is its gene product?

A

Oncogene; Tyrosine kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is another name for the HER2/neu gene?

A

HER2/neu (c-erbB2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What tumor is associated with L-myc gene?

A

Lung tumor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What type of gene is L-myc? What is its gene product?

A

Oncogene; Transcription factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What tumor is associated with N-myc gene?

A

Neuroblastoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What type of gene is N-myc? What is its gene product?

A

Oncogene; Transcription factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What 3 tumors are associated with ras gene?

A

Colon cancer, lung cancer, pancreatic cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What type of gene is ras? What is its gene product?

A

Oncogene; GTPase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What tumors are associated with ret gene?

A

MEN 2A and 2B

22
Q

What type of gene is ret? What is its gene product?

A

Oncogene; Tyrosine kinase

23
Q

What change to tumor suppressor genes increase cancer risk? How many alleles must be affected to cause this?

A

Loss of function => increase cancer risk; both alleles must be lost for expression of disease.

24
Q

What tumor is associated with APC gene?

A

Colorectal cancer (associated with FAP)

25
Q

Again, what tumor is associated with APC? With what condition is this associated?

A

Colorectal cancer (associated with FAP) [i.e., FAP = Familial adenomatous polyposis)

26
Q

What kind of gene is APC?

A

Tumor suppressor gene

27
Q

What 2 tumors are associated with BRCA1 gene? With what other gene are they also associated?

A

Breast and ovarian cancer; BRCA2

28
Q

What kind of genes are BRCA 1 and BRCA2? What is their gene products?

A

Tumor suppressor genes; DNA repair protein

29
Q

What tumor is associated with CPD4/SMAD4 gene?

A

Pancreatic cancer

30
Q

What kind of gene is CPD4/SMAD4? What is its gene product?

A

Tumor suppressor gene; Think: “Deleted in Pancreatic Cancer”

31
Q

What is another name for CPD4 gene?

A

SMAD4

32
Q

What tumor is associated with DCC gene?

A

Colon cancer

33
Q

What kind of gene is DCC? What is its gene product?

A

Tumor suppressor gene; Think: “Deleted in Colon Cancer”

34
Q

What tumor(s) is (are) associated with MEN1 gene?

A

MEN type 1

35
Q

What tumor(s) is (are) associated with NF1 gene?

A

NeuroFibromatosis type 1

36
Q

What kind of gene is NF1? What is its gene product?

A

Tumor suppressor gene; RAS GTPase activating protein (neurofibromin)

37
Q

What tumor(s) is (are) associated with NF2 gene?

A

NeuroFibromatosis type 2

38
Q

What kind of gene is NF2? What is its gene product?

A

Tumor suppressor gene; Merlin (schwannomin) protein

39
Q

What tumor is associated with p16 gene?

A

Melanoma

40
Q

What kind of gene is p16? What is its gene product?

A

Tumor suppressor gene; Cyclin-dependent kinase inhibitor 2A

41
Q

What tumor(s) is (are) associated with p53 gene?

A

Most human cancers, Li-Fraumeni syndrome

42
Q

What kind of gene is p53? What is its gene product? What is its function?

A

Tumor suppressor gene; Transcription factor for p21, blocks G1 => S phase

43
Q

What 3 tumors are associated with PTEN gene?

A

Breast cancer, prostate cancer, endometrial cancer

44
Q

What 2 tumors are associated with Rb gene?

A

Retinoblastoma, osteosarcoma

45
Q

What kind of gene is Rb? What is its gene product? What is its function?

A

Tumor suppressor gene; Inhibits E2F; blocks G1 => S phase

46
Q

What tumor(s) is (are) associated with TSC1?

A

Tuberous sclerosis

47
Q

What kind of gene is TSC1? What is its gene product?

A

Tumor suppressor gene; Hamartin protein

48
Q

What tumor(s) is (are) associated with TSC2?

A

Tuberous sclerosis

49
Q

What kind of gene is TSC2? What is its gene product?

A

Tumor suppressor gene; Tuberin protein

50
Q

What tumor(s) is (are) associated with VHL?

A

von Hippel-Lindau disease

51
Q

What kind of gene is VHL? What is the function of its gene product?

A

Tumor suppressor gene; Inhibits hypoxia inducible factor 1a

52
Q

What tumor(s) is (are) associated with WT1? What other gene shares the same association(s)?

A

Wilms Tumor (nephroblastoma); WT2

FA - Pathology (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions