Path: diagnositc principles

Question 1

What are cytokeratins?

Answer 1

collection of proteins that highlight benign and malignant epithelial cells.

Question 2

What is vimentin?

Answer 2

intermediate filament expressed in CT tumors and melanomas

Question 3

What is leukocyte common antigen?

Answer 3

Found in leukemias and lymphomas

Question 4

What is CD20?

Answer 4

protein found on B lymphocytes

Question 5

What is CD3?

Answer 5

protein found on T lymphocytes

Question 6

What is CD31?

Answer 6

marker for endothelial cells used to verify vascular tumors

Question 7

What is smooth muscle actin/SMA?

Answer 7

stains actin intermediate filaments to contractile smooth muscle cells. myofibroblastic and myopeithelial cell tumors express this marker

Question 8

What is desmin?

Answer 8

muscle marker

Question 9

What is S100?

Answer 9

intermediate filament that stains neural cell walls and other cell types like melanocyte and cartialge. employed for neural and ganular cell tumors as well as melanocytic lesions.

Question 10

What is HMB-45?

Answer 10

Stains some, but not all, melanomas.