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path antibodies to learn Flashcards

1
Q

Autoimmune hepatitis

A

Anti-smooth muscle antibody, Anti Liver Kidney microsomal-1 (anti-LKM-1). Anti-Soluble Liver Antigen (anti-SLA)

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2
Q

Autoimmune haemolytic Anaemia

A

Anti-Rh Blood Group Antigen

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3
Q

Autoimmune Thrombocytopenic Purpura

A

Anti-Glycoprotein IIb-IIIa or Ib-IX Antibody

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4
Q

Bullous Pemphigoid

A

Anti-hemidesmosome

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5
Q

Coeliac disease

A

Anti-tissue transglutaminase antibody (IgA), Anti-endomysial antibody (IgA)

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6
Q

Congenital heart block in infants of mothers with SLE

A

Anti-Ro antibody

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7
Q

Dermatitis herpetiformis

A

Anti-endomysial antibody (IgA)

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8
Q

Goodpasture’s Syndrome

A

Anti-Glomerular basement membrane Antibody

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9
Q

Graves’ Disease

A

Anti-TSH Receptor Antibody (stimulatory antibody)

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10
Q

Hashimoto’s Thyroiditis

A

Antibodies to Thyroglobulin and Thyroperoxidase

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11
Q

Myasthenia Gravis

A

Anti-Ach Receptor Antibody

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12
Q

Pernicious anaemia

A

Antibody to gastric parietal cells (90%) and intrinsic factor (50%)

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13
Q

Primary biliary cirrhosis

A

Anti-mitochondrial antibody

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14
Q

Type 1 Diabetes Mellitus

A

Antibodies to Glutamate Decarboxylase and pancreatic β Cells

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15
Q

Rheumatoid Arthritis

A

RF and Anti-CCP (more specific)

  • Factors that increase amount of citrullinated peptide:
    o HLA- DR4
    o PADI (peptidlyarginine deaminase)
    o TPT-22 polymorphism
    o Smoking
    o Gingivitis
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16
Q

SLE

A

Anti ds-DNA, anti-histone, anti-ribosome

17
Q

Sjogren’s

A

Anti-Ro and Anti-La
Destruction of exocrine glands

18
Q

Dermatomyositis

19
Q

Polymyositis

20
Q

CREST

A

Anti-Centromere

21
Q

Diffuse CREST

A

Anti-Scl70 (anti-topoisomerase)

22
Q

Granulomatosis with Polyangiitis
(Wegner’s)

A

cANCA- directed against proteinase 3

23
Q

Eosinophilic Granulomatosis with Polyangiitis (Churg Strauss)

A

pANCA- directed against myeloperoxidase

24
Q

Microscopic Polyangiitis

A

pANCA- directed against myeloperoxidase

25
Q

Psoriatic arthritis (HLA..)

26
Q

Ankylosing spondylitis (HLA..)

27
Q

Reactive Arthritis (HLA…)

28
Q

IBD (HLA…)

29
Q

HLA B27

A

PAIR
Psoriatic arthritis
Ankylosing spondylitis
IBD
Reactive Arthritis

30
Q

Goodpasture’s syndrome (HLA..)

A

HLA DR15/DR2

31
Q

Graves’ Disease (HLA…)

32
Q

Systemic Lupus Erythematosus (SLE) (HLA…)

33
Q

Type I diabetes hla?

A

HLA DR3/DR4

34
Q

Rheumatoid arthritis hla?

A

HLA-DR4 (4 walls in a rheum)

35
Q

Coeliac Disease hla?

A

DQ2/DQ8 (I ate (8) too (2) much)

Dylan's flashcards (14 decks)

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