Path 4- Disease Associated with pregnancy/Turmors

Question 1

Hepatic disease associated with pregnancy

most ccommon cause of jaundice in pregnancy? (types) does pregnancy complicate this?

one exception?

small percentage can have what disorders that are directly attributable to pregnancy? 3

Answer 1

Question 2

Preeclampsia and eclampsia

p- characterized by?4 is eclampsia when? dangerous?

can be part of what syndrome?

morph- pre- what structure contains what? where? leads to? bad?

elevation of? if severe?

Answer 2

Question 3

Acute fatty liver of pregnancy

presents with? present at what time? symptoms? 4 can present as?

morph- diagnose via? characteristic? distinction from what is difficult?

commonly severe? but? treatment? could be dysfunction of?

deficiency? rare instance of fetus doing what?

Answer 3

Question 4

Intrahepatic cholestasis of pregnancy

characteristic signs? 3 what is high? mainly?

caused by?

severe? but?

Answer 4

Question 5

Nodular Hyperplasias

how many? develop in what type of liver? two different types? blood supply?

morph- focal- appear as? size? in what type of liver? age? color? 2 if second? pretty unique? what is ti?

Nod- type of liver? similar to? but without? can lead to development of? in association with what?

Answer 5

Question 6

Benign Neoplasms

most common?

HCA? developing from what cell? symtptoms? emergency if?

2 drugs associated with it?

Answer 6

Question 7

hepatocelluar Adenoma path

three subtypes? which is highest chance malig?

H- what is mutated? this encodes for? need what to be an adenoma? gender?

b- activation of? associated with?

I- gender? mutatiuon? a receptor for? this uses what pathway?

Answer 7

Question 8

Hepatocelluar adenoma morph

h- look like? malignant? expressed a lot?

b- look like? diagnostic change? need what for definitive confirmation?

i- differ from other two how? over express?

Answer 8

Question 9

Malignant tumors

two types? if from hepatocytes? less common carcinoma?

rare? H

H-most common liver tumor of? age?

two types? e- composed of? m- composed of

frequent activation of? so can often have what disease as well? highly expressed assoicated with what disease?

Answer 9

Question 10

HCC

most cases occur in countries with? countries? age? toxin? can help rates decline?

western countries- increasing due to?

age? malig emerges after? gender?

Answer 10

Question 11

HCC path 1

most common setting for HCC? timing?

most important underlying factors? 2

co-infection? contaminated food crops?

afla synergizes with? alcohol? cigs?

type of disease can increase chance?

Answer 11

Question 12

HCC path 2

mutations? but activation of? inactivation?

more unrelated to HBV if? strong association with aflatoxin? are these in premalignant lesions?

how chronic infal goes to HCC?

thorugh what signalling? one bigger one?

Answer 12

Question 13

Answer 13

Question 14

Precurso lesions of HCC

b-catenin associated?

chronic liver there are? 2

s- is what? l- is?

dysplatic nodules usually detected i? differ from surroundings hwo?

whihc has higher risk for HCC?

high grade dysplastic nodules?

Answer 14

Question 15

HCC morph

large cell- cells? where? size? nujber? what is normal?

small- what is high?

low grade dyspstic nodules- devoid of? but? blood supply?

high grade- have? blood?

Answer 15

Question 16

HCC morph 2

HCC may appear as? 3

involve how much of liver? diffusely infiltrative shows as? color?

Intrahepatic metastases- by what mechanisms? 2 at what size? to what place?

but can also be where? not usually where?

tumor reccurence in what pop?

Answer 16

Question 17

HCC morph 3

differentiated? variant of HCC? is ? age? look like? hardness? bands? rich in?

Answer 17

Question 18

HCC clin

manifestations? often masked by? in jamaica?

but can have? 5

can have increased what? but?

most valuable diag? US for? CT/MRI for?

natural course of tumor?

death via? 4

size? good outcome

Answer 18

Question 19

CCA

second most common what? location? countries? why?

all risk factors cuase?

these risk factors? 3

3 that can go to both this and HCC?

preexisting conditions?

Answer 19

Question 20

CCA 2

location in liver? e- forms what tumor? lcoated?

half are what type of tumors? location?

prognosis? come to attention due to?

premalignant lesions? most important?

Answer 20

Question 21

CCA morph

extra- size when diagnosed? why? color? location?

intra- occur in what liver? lovcation?

typical of what type of tumor? so you see?

Answer 21

Question 22

Other hepatic malignant tumors

combined? origin from?

angiosarcoma- can be caused by?

hepatic lymphomas- gender? age? in associated with? type of lymphoma?

Answer 22

Question 23

Metasasis

more common than? most common sources? 4

number of nodules? causes?

this is weird becaue?

often only telltale sign is?

Answer 23