Path 3-Jaundice/Cholestasis/Cholangitits/Blood flow

Question 1

Jaundice

types of bilirubin? which is insoluble in water? can be in blood? problem? what caln lead to accumulation? (in newborn disease) which leads to?

wate rsoluble? losely bound to? excreted whre?

normal bilrubin in blood? jaundice when?

Answer 1

Question 2

Answer 2

Question 3

Neonatal Jaundice

what isnt mature? until? type of bilirubin? exacerbated by?

hereditary hyperbilirubinemias

mutation? chromosome? leads to? 3

conjugated? 2

Answer 3

Question 4

Question 5

Cholestasis

what is it caused by? gives rise to? caused by? 3

symptoms? 4

elevated serum? 2 where?

Morph-common to obstructive/nonobstructive? color?accumulations of? where? called??

Answer 5

Question 6

Large bile duct obstruction

most common cause of duct obstruction? followed by? 2 in children?4

reversible? prolonged obstruction goes to?

if subtotoal or intermittent obstruction? cholangittis symtpoms? worse type?

morph- upstream? hallmark of ascending?

uncorrected goes to? 2 degen? bodies?

treatment?

Answer 6

Question 7

Cholestasis of sepsis

affect liver by what mechanisms? 3

whihc is most likely? if what type?

most common form is? seen on histo? cells?

more ominous? location?

leads to what problem?

Answer 7

Question 8

Primary hepatolithiasis

location? formation of? leads to?3

morph- type of stones? location? ducts show?

clin- present with? due to? marked by?

seen oiun parenchyma?

sometimes seen mistaken for what?

cancer?

Answer 8

Question 9

Neonatal cholestasis

what is it? type? timing? major casues are? 2

neonatal hepatitis?

differentiation of what is important? why?

symptoms? 4

morph- liver cells? transformation? change in what cells? extramedullary?if blend in?

Answer 9

Question 10

Biliary atresia

what is it? timing? can lead to? most frequent casue of?

path- two major forms? more common?

f- associated with? 3 cause is?

p-what happens?

Answer 10

Question 11

Biliary atresia

morph- problem? where? leads to duct? cirrhosis? surg correctable if? not if?

clin-present with? age? whats normal? what changes from normal?

if not correctable then treat how?

Answer 11

Question 12

Answer 12

Question 13

primary biliary cirrhosis

autoimmune disease characterized by? location? diagnosed when often? gender? race?

path- antibodies most characteristic? recognize what? component of? also against this?

MHC? antibodies against what else?

Answer 13

Question 14

PBC

morph- location? destroyed by? with or without what? is it diffuse? increasing what? end stages? location of bile accumulation? compared to?also seen? color?scar tissue?

big difference compared to other cirrhotic livers?

clin- diagnosed when? labs? antibody? biopsy diagnostic if? symptoms?

untreated what happens? 2 treatment?

secondary features?

Answer 14

Question 15

PSC

characterized by? location? charactersitic? often seen with what disease? age? gender?

path-type of cell in stroma? autoantibody association to HLA what?

Autoantibody often seen?

Answer 15

Question 16

PSC

morph- in large ducts? similar to? cell type? develop what characterstic property

small- have what? also big histo item? diagnsostic?

Clin- asymptomatic patients may come to attention only due to? if symptoms what symptoms?

timing? gi problem? type of cancer?

can be combo disease with? treatment?

Answer 16

Question 17

Choledochal cysts

what are they? location?

age? present with? gender?

form of? similar to? predispose to?

Answer 17

Question 18

fibropolycystic disease

what is it? location? severe? manifest as? in absence of?

Answer 18

may want more info pg. 861

Question 19

Impaired blood flow into the liver

2 causes?

Hep- infarcts? can be caused by? 2 helps sustain? one exception?

Answer 19

Question 20

Portal vein obstruction and thromb

well tolerated? seen as? other manifestation?

not common?

extrahepatic obstruction caused by? 7

Intrahepatic obstructed by? results in? called?

Answer 20

Question 21

Portal vein obstruction

small portal vein branch diseases

most common casue?other disease?

present with? common location (geograph)

other organ?

Answer 21

Question 22

Impaired blood flow through the liver

most common? other diseases?

obstruction to blood flow amy lead to?

peliosis hepatitis is what?

if AIDS associated? also seen in?

big problem?

Answer 22

Question 23

Hepatic venous outflow obstruction

Hepatic vein thrombosis- how many? causes? 3 this is named? if only one vien?

associated with? in women?

morph- liver is? color?alternating? chronic cases?

mortality untreated? treat with?

Answer 23

Question 24

Hepatic venous outflow obstruction

Sinusoidal obstruction syndrome- seen frist in? two settings?

path- what is obstructed? casued by? what blocks? blood enters where? necrosis where?

morph- charcahterized by? acute?3 progresses to?

gold standard diagn? but can be? dont do what?

Answer 24