Path 3-Jaundice/Cholestasis/Cholangitits/Blood flow Flashcards
Jaundice
types of bilirubin? which is insoluble in water? can be in blood? problem? what caln lead to accumulation? (in newborn disease) which leads to?
wate rsoluble? losely bound to? excreted whre?
normal bilrubin in blood? jaundice when?
Neonatal Jaundice
what isnt mature? until? type of bilirubin? exacerbated by?
hereditary hyperbilirubinemias
mutation? chromosome? leads to? 3
conjugated? 2
Cholestasis
what is it caused by? gives rise to? caused by? 3
symptoms? 4
elevated serum? 2 where?
Morph-common to obstructive/nonobstructive? color?accumulations of? where? called??
Large bile duct obstruction
most common cause of duct obstruction? followed by? 2 in children?4
reversible? prolonged obstruction goes to?
if subtotoal or intermittent obstruction? cholangittis symtpoms? worse type?
morph- upstream? hallmark of ascending?
uncorrected goes to? 2 degen? bodies?
treatment?
Cholestasis of sepsis
affect liver by what mechanisms? 3
whihc is most likely? if what type?
most common form is? seen on histo? cells?
more ominous? location?
leads to what problem?
Primary hepatolithiasis
location? formation of? leads to?3
morph- type of stones? location? ducts show?
clin- present with? due to? marked by?
seen oiun parenchyma?
sometimes seen mistaken for what?
cancer?
Neonatal cholestasis
what is it? type? timing? major casues are? 2
neonatal hepatitis?
differentiation of what is important? why?
symptoms? 4
morph- liver cells? transformation? change in what cells? extramedullary?if blend in?
Biliary atresia
what is it? timing? can lead to? most frequent casue of?
path- two major forms? more common?
f- associated with? 3 cause is?
p-what happens?
Biliary atresia
morph- problem? where? leads to duct? cirrhosis? surg correctable if? not if?
clin-present with? age? whats normal? what changes from normal?
if not correctable then treat how?
primary biliary cirrhosis
autoimmune disease characterized by? location? diagnosed when often? gender? race?
path- antibodies most characteristic? recognize what? component of? also against this?
MHC? antibodies against what else?
PBC
morph- location? destroyed by? with or without what? is it diffuse? increasing what? end stages? location of bile accumulation? compared to?also seen? color?scar tissue?
big difference compared to other cirrhotic livers?
clin- diagnosed when? labs? antibody? biopsy diagnostic if? symptoms?
untreated what happens? 2 treatment?
secondary features?
PSC
characterized by? location? charactersitic? often seen with what disease? age? gender?
path-type of cell in stroma? autoantibody association to HLA what?
Autoantibody often seen?
PSC
morph- in large ducts? similar to? cell type? develop what characterstic property
small- have what? also big histo item? diagnsostic?
Clin- asymptomatic patients may come to attention only due to? if symptoms what symptoms?
timing? gi problem? type of cancer?
can be combo disease with? treatment?
Choledochal cysts
what are they? location?
age? present with? gender?
form of? similar to? predispose to?
fibropolycystic disease
what is it? location? severe? manifest as? in absence of?
may want more info pg. 861
Impaired blood flow into the liver
2 causes?
Hep- infarcts? can be caused by? 2 helps sustain? one exception?
Portal vein obstruction and thromb
well tolerated? seen as? other manifestation?
not common?
extrahepatic obstruction caused by? 7
Intrahepatic obstructed by? results in? called?
Portal vein obstruction
small portal vein branch diseases
most common casue?other disease?
present with? common location (geograph)
other organ?
Impaired blood flow through the liver
most common? other diseases?
obstruction to blood flow amy lead to?
peliosis hepatitis is what?
if AIDS associated? also seen in?
big problem?
Hepatic venous outflow obstruction
Hepatic vein thrombosis- how many? causes? 3 this is named? if only one vien?
associated with? in women?
morph- liver is? color?alternating? chronic cases?
mortality untreated? treat with?
Hepatic venous outflow obstruction
Sinusoidal obstruction syndrome- seen frist in? two settings?
path- what is obstructed? casued by? what blocks? blood enters where? necrosis where?
morph- charcahterized by? acute?3 progresses to?
gold standard diagn? but can be? dont do what?
