Pasteurella

Question 1

Pasteurella multocida

Answer 1

Capsule: types A-E (antigenic properties)

Type A = mucoid -> capsule + hyaluronic acid

Question 2

Pasteurella multocida

Virulence Factors

Answer 2

Adhesins - fimbriae and OMPs
Capsule - adherence, anti-phagocytic, anti-complement
Cell wall - LPS
Iron Acquisiton - siderophores and OMPs

Question 3

Pasteurella multocida

Virulence Factors - Toxins

Answer 3

RTX - leukotoxin and lysis of erythrocytes; impairs pulmonary macrophage function; inflammatory reaction with tissue destruction
Rho activating toxin

Question 4

High and low virulent strains of Pasteurella multocida

Answer 4

High virulent strains:
obligate pathogenic - septicemia; bovines, birds, rabbits

Low virulent strains:
facultative pathogenic - rhinitisl pneumonia; pigs, bovines, rabbits

Question 5

Pasteurella multocida in rabbits

Answer 5

Rhinitis (snuffles)
May evolve to:
pleuropneumonia, otitis, conjunctivitis, abscesses

Question 6

Pasteurella multocida in bovines

Answer 6

High pathogenic serovars: hemorrhagic septicemia
High mortalities
Carriers (tonsils)

Question 7

Pasteurella multocida in pigs

Answer 7

Atrophic rhinitis
Lung pasteurellosis - capsul type A and somatic type 3
Aerosol transmission
Carriers (n0se)
Suppurative bronchopneumonia and fibrinous pleuritis

Question 8

Pasteurella multocida in poultry

pathogenesis

Answer 8

Fowl cholera
Susceptibility differences:
duck>goose>turkey>chicken>pheasant>partridge>guinea fowl
In nose and beak of healthy animals
Entrance - mucosae mouth, throat, trachea, skin lesions
Septicemia

Question 9

Pasteurella multocida in poultry symptoms

Answer 9

Fowl cholera
Chicken and turkey:
mainly young adult
Acute: sudden death
Cat bites: always hyperacute in all bird species

Question 10

Pasteurella multocida in cats and dogs

Answer 10

Licking of wounds
Biting wounds and scratch lesions
Cats bite a bird = bird gets septicemia; bird will not survive the infection
Less virulent serotypes - nose, tonsils