past papers

Question 1

in ankylosing spondylitis, RA, PA, IBD and FMF whihc cytokine should be targetted

give an example of a drug?

Answer 1

anti-TNFa

infliximab

Question 2

Etanercept

Answer 2

TNFa/beta receptor protein inhibits both

RA
AS
psoriatic arthritis

Question 3

Natalizumab is a?
targets?
for?

Answer 3

agent directed against cell surface antigens
blocks signalling

against: anti-alpha-4-beta 1 integrin

Multiple sclerosis

Question 4

anti-cd25 important for allograft rejection prophylaxis

Answer 4

basiliximab

Question 5

Riuximab targets?

Answer 5

anti-Cd20

depletes mature b cells

useful in lymphoma

Question 6

organ transplant rejection prophylaxis - IL2 receptor ab

Answer 6

targets cd25

daclizumab

Question 7

what is the max number of HLA mismatch

if a parent is a kidney donor to child

Answer 7

3

Question 8

what happens in gVhd

Answer 8

donor lymphocytes attack host HLA

Question 9

what does a depot adjuvant do?
like alum

Answer 9

enhancement of immune response

Question 10

which antibiologic targets and if efficacious in RA but not in psoraitic arthritis

Answer 10

tocilizumab - IL6 receptor inhibitor

Question 11

smoking and immune dysfunction

Answer 11

smoke increases citrullination of proteins in lungs