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Year 5 Immuno > MEDgems 3 > Flashcards

MEDgems 3 Flashcards

1
Q

first line treatment for febrile non haemolytic transfusion reaction?

A

paracetamol

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2
Q

drug given to infants at high risk of RSV - spell it out

A

pali vi zumab

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3
Q

in x linked scid
are b cells normal?
are t cells normal?
NK cells?

A

b cells are NORMAL/ raised

low/absent t cell
absent NK

mutation in gamma chain of il2 on xq13.1 so immature b cell and no t /nk

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4
Q

bruton’s x linked hypogammaglobulinaemia

what is b cell?
t cell?

A

no mature b cell and no circulating after 3 months

t cell normal

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5
Q

John Cunningham Virus causes?

A

progressive multifocal leukoencephalopathy

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6
Q

what HLA which graves?

A

HLA-Dr3

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7
Q

SLE HLA?

A

HLA-DR3

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8
Q

goodpastures HLA?

A

HLA DR15, DR2

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9
Q

T1DM HLA?

A

HLA-DR3/DR4

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10
Q

what cytokine is predominant for t cell proliferation?

A

IL-2

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11
Q

what exists for detection of allergen specific IgE in blood?

A

Radioallergosorbent test

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12
Q

what is used for diagnosis of type 4?

A

path testing

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13
Q

what is the vaccine type that uses preformed antigenic proteins?

A

subunit vaccine - used for viruses

hep b
HPV

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14
Q

what is in a conjugate vaccine?

A

bacterial polysaccharide
immunogenic toxin

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15
Q

agglutination is?

A

immunoglobulins bindging to as many pathogens as possible

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16
Q

anti phospholipid syndrome
what autoantibodies?

A

anti cardiolipin
anti-B2 glycoprotein

17
Q

Neutralisation is ?

A

the provess by which a target is covered in autoantibodies
so it can’t enter human cell

18
Q

Hypersegmented neutrophils are indicative of megaloblastic anemia a condition seen in?

A

alcoholics

19
Q

what antibody is secreted in breast milk?

A

IgA

20
Q

What is the short-term treatment for severe, life threatening antibody mediated damage

A

plasmapharesis

21
Q

what blood product is most commonly associated with bacteria?

A

platelets

22
Q

70 year old, kidney failure and haematuria

weight loss
started coughing blood

what immunological condition?

A

goodpastures

23
Q

target of p anca?

A

Myeloperoxidase

24
Q

what can be given to treat CGD

A

interferon gamma

25
Q

what is the main metabolite of azathiopurine?

A

6-Mercaptopurine

26
Q

What assay is used as the first line test for HIV infection?

A

enzyme linked immunosorbent assay

27
Q

What antigen does the immune system erroneously target in autoimmune thrombocytopenic purpura?

A

glycoprotein IIb/IIIa

28
Q

How may mast cell degranulation be measured?

A

mast cell tryptase

29
Q
A

Year 5 Immuno (8 decks)

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