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Year 5 Immuno > MEDgems > Flashcards

MEDgems Flashcards

1
Q

monoclonal antibody treats MS - targets alpha4 integrin

A

natalizumab

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2
Q

psoriasis: Il-23
IL-12

A

Ustekinumab

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3
Q

receptor initial binding of HIV protein?

A

gp120

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4
Q

rosary bead” appearance of small aneurysms
renal

A

polyarteritis nodosa

typical site for biopsy is Sural nerve

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5
Q

CD14 is a marker of ?

A

monocytes

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6
Q

sjogren what malignancy at risk of?

A

mucosa associated lymphoid tissue lymphoma

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7
Q

what virus is polyarteritis nodosa associated with?

A

hep B

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8
Q

IgG binds to?

A

monomeric
2 specific site

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9
Q

What blood product is most commonly contaminated by bacteria?

A

bacteria

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10
Q

The family of a 13 year old boy with a known latex allergy have kept a food diary after they noticed some foods make his skin itchy. They noticed that bananas, potatoes, tomatoes and mangos may precipitate an outbreak. What specific allergic condition does he suffer from?

A

latex food syndrome

IgE type 1 cross recats with latex antigen

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11
Q

oral or oesophageal candidiasis

A

white pseudomembrane
tired, diff swallowing

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12
Q

autoantibody - Graves useful makrker for thyroid cancer?

A

anti-thyroglobulin
produced in response to thyroid cells

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13
Q

autoantibody targeting Cd25

A

basiliximab
allograft rejection

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14
Q

Tofacitinib treats?

A

RA, UC

inhibits tyrosine kinase
JAK

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15
Q

steroid side effect?

A

avascular necrosis of femoral head
HTN
tarnsient neutrophilia

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16
Q

abscess formation, staph aureus infection, neutropenia

first month of life?

A

Kostmann syndrome

17
Q

how to differentiate between diffuse and limited?

A

ESR raised
fatigue
weight loss
scleroderma beyond elbows / upper limbs is also suggestive of diffuse

18
Q

HIV belongs to

A

Retroviridae

19
Q

example of CAR-T

A

tisagenlecleucel

chimeric antigen receptor t cell

20
Q

what is a CAR-T

A

gene containing t cell recpetor - cd3 specific to cancer is inserted into DNA of t cells using virus

resulting t cell hybrids then grown in a lab and reinfused into patient

CAR-T meet cancer cell and t cells activate and kill cancer cell

21
Q

example of CAR-T therapy?

A

b cell acute lymphoblastic leukaemia
large B cell lymphoma

22
Q

what subset of t helper cells associated with transcription factor foxp3?

A

t regulatory cells - CD25+
inhibit immune response by secreting IL10 - immunosuppresive cytokine

23
Q

immunosuppresive cytokine?

A

IL10
secreted by CD25

24
Q

IgA can bind to ?

A

4 capsids

Year 5 Immuno (8 decks)

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