PassPharm Flashcards
Hepatotoxicity is/are most characteristically caused by:
Isoniazid Aminoglycosides TCAs Halothane Levodopa Lamotrigine
Halothane.
Isoniazid causes peripheral neuropathy.
Thrombophlebitis is most characteristically caused by:
Levodopa Metoclopramide Quinidine Nitrofurantoin Methotrexate Tamoxifen
Thrombophlebitis can be caused by:
Amiodarone
Vancomycin
Tamoxifen
Methotrexate causes mucositis.
What is the treatment of choice for migraine prophylaxis (not a women or childbearing age)?
Triptan + NSAID or triptan + paracetamol Amitriptyline Frovatriptan or zolmitriptan Paroxetine Propranolol Topiramate or propranolol
Topiramate or propranolol: migraine prophylaxis (not a women of childbearing age).
Frovatriptan or zolmitriptan: prophylaxis against menstrual migraine.
Hyponatraemia is most characteristically caused by:
Rifampicin Pioglitazone Valproic acid Lithium Sulfonylureas TCAs
Hyponatraemia: Thazides Loop diuretics Carbamazepine Sulfonylureas TCAs
Tremor: Sodium valproate Lithium Antipsychotics Valproic acid Ciclosporin
What effect does fluconazole have on the p450 system?
Inhibitor
Is omeprazole an enzyme inhibitor or inducer?
Inhibitor
Which of the following adverse effects is most characteristically associated with sodium valproate?
Skin necrosis Nystagmus Confusion Myelosuppression/agranulocytosis Ataxia Urinary retention
Ataxia: Phenytoin Sodium valproate Carbamazepine Valproic acid Amantadine
Ataxia is a term for a group of disorders that affect co-ordination, balance and speech.
What effect does chronic alcohol intake have on P450 system?
Inductor
Which one of the following is an example of a P450 enzyme inhibitor?
Phenytoin Smoking Rifampicin St Johns Wort Chronic alcohol intake Amiodarone
Amiodarone is an enzyme inhibitor.
Which one of the following effects is most characterically associated with etanercept?
Fever Tardive dyskinesia Peripheral neuropathy Osteonecrosis of the jaw Retinopathy Hyperthyroidism
Phenytoin = fever. Etanercept = peripheral neuropathy.
Which of the following is most characteristic of lead poisoning?
Hyperpyrexia Peripheral neuropathy Miosis Pink skin and mucosae Bradycardia
Lead = peripheral neuropathy. Miosis = organophosphate insectidine poisoning.
Which of the following is most likely to represent a contraindication to the prescription of hydralazine?
Concurrent statin therapy CKD (eGFR <30ml/min/1.73m^2) Recent myocardial infarction Concurrent nitrate therapy Heart failure Asthma
Nitrate: PDE5 (sildenafil)
Recent myocardial infarcton: Metformin Sildenafil Sumatriptan Hydralazine
Peripheral neuropathy is most characteristically caused by:
Cytarabine Fluorouracil Cyclophophamide Cisplatin Bleomycin Methotrexate
Peripheral neuropathy:
Vincristine
Cisplatin
Vinblastine
Pulmonary fibrosis:
Bleomycin
Methotrexate
