Passive vs Active immunity, Vaccination Flashcards
Immunity that involves receiving preformed antibodies
Passive immunity
Immunity that involves exposure to antigens
Active immunity
Onset of passive immunity
Rapid
Onset of active immunity
Slow
Duration of passive immunity
Short span, about 3 weeks = half-life of antibodies
Duration of active immunity
Long-lasting immunity (memory)
IgA in breast milk is what type of immunity?
Passive
Maternal IgG crossing placenta is what type of immunity?
Passive
Antitoxins via vaccine is what type of immunity?
Passive
Receiving humanized monoclonal antibodies is what type of immunity?
Passive
Natural infection is what type of immunity?
Active
Vaccines are what type of immunity?
Active
Receiving toxoids is what type of immunity?
Active
Unvaccinated patients exposed to Tetanus or Botulinum toxin, HBV, Varicella, Rabies virus or diphtheria antitoxin are given…
preformed antibodies (passive immunity)
Combined passive and active immunizations can be given for…
hepatitis B or rabies exposure
Effects of vaccination
Induce an active immune response (humoral and/or cellular) to specific pathogens
Pros of live attenuated vaccines
Induce strong, often lifelong immunity
Cons of live attenuated vaccines
May revert to virulent form, often contraindicated in pregnancy and immunodeficiency
Vaccination type where microorganism loses its pathogenicity but retains capacity for growth within inoculated host
Live attenuated vaccine
Type of vaccination that induces both humoral and cellular response
Live attenuated vaccine
Live vaccines like MMR and varicella may be given to HIV patients with a CD4 count of…
> 200/mm3
BCG, influenza (intranasal), measles, mumps, polio (Sabin), rotavirus, rubella, varicella, yellow fever are examples of what type of vaccine?
Live attenuated vaccines
Vaccine where pathogen is destroyed by heat or chemicals
Inactivated or killed vaccines
Maintaining what structure in inactivated or killed vaccines is important for immune response?
Epitope structure on surface antigens
Which vaccine type mainly induces a humoral response?
Inactivated or killed vaccine
Pros of Inactivated or killed vaccine
Safer than live vaccines
Cons of Inactivated or killed vaccine
Weaker immune response; may require booster shots
Rabies, Influenza (injection), Polio (Salk), Hep A are examples of what type of vaccine
Inactivated or killed vaccines