Helper T cells, Cytotoxic T cells, Regulatory T cells Flashcards
Differentiated Helper T-cell
Th1, Th2, Th17, T-reg
Cytokine that causes T-cell to change to T-reg
TGF-beta
Cytokine that causes T-cell to change to Th17 cell
TGF-beta and IL-6
Cytokine that causes T-cell to change to Th2 cell
IL-2, IL-4
Cytokine that causes T-cell to change to Th1 cell
IL-12, IFN-gamma
Cytokine that inhibits Th1 cell
IL-4, IL-10 from Th2 cell
Cytokine that inhibits Th2 cell
IFN-gamma from Th1 cell
Th1 cell activates what cell types
Macrophages and cytotoxic T-cells
Cytokines secreted by Th1 cell
IFN-gamma and IL-2
Cytokines secreted by Th2 cell
IL-4, IL-5, IL-6, IL-10, IL-13
Th2 cell induces B cells to secrete…
IgE
Th2 cell recruits what immune cell?
Eosinophils for parasitic defense
Th1 cells release what to stimulate macrophages?
IFN-gamma
T cell differentiation to Th1 is cause by what cells?
Release of IL-12 by dendritic cells, macrophages and other APCs
Function of Cytotoxic T cells
Kill virus infected, neoplastic or donor graft cells by inducing apoptosis
Mechanism how Cytotoxic T cells induce apoptosis
Release cytotoxic granules containing preformed proteins (perforin, granzyme B)
Function of Regulatory T Cells (T-regs)
Maintain specific immune tolerance by suppressing CD4 and CD8 T-cell effector functions
Surface proteins expressed by T-regs
CD3, CD4, CD25, FOXP3
Anti-inflammatory cytokines produced by activated T-regs
IL-10, TGF-beta
Genetic deficiency of FOXP3 leading to autoimmunity
IPEX (Immune dysregulation, Polyendocrinopathy, Enteropathy, X-linked) syndrome
IPEX is associated with what group of individuals
Diabetes in male infants
IPEX is characterized by…
Enteropathy, endocrinopathy, nail dystrophy, dermatitis, and/or other autoimmune dermatologic conditions
