Hypersensitivity types Flashcards
Mast cells and basophils releasing cytokines that induce cellular inflammation is seen in…
Delayed phase of Type I hypersensitivity reaction
Type I hypersensitivity reaction immediate phase involves…
immediate release of vasoactive amines at postcapillary venules
Reaction of type I hypersensitivity reaction occurs rapidly because of…
preformed antibodies
Anaphylatic and atopic reaction is what type of hypersensitivity reaction
Type I
What antibody cross-links on presensitized mast cells and basophils
IgE
IgE cross-linking on presensitized mast cells and basophils triggers…
immediate release of histamine at postcapillary venules
Food, drug, or bee stings causing anaphylaxis are examples of…
Type I hypersensitivity reaction
Skin test or blood test like ELISA for allergen-specific IgE illicits what hypersensitivity reaction?
Type I
Test that detects antibodies attached to RBC surface
Direct Coombs test
Test that detects presence of unbound antibodies in serum
Indirect Coombs test
Direct and Indirect Coombs test are what type of hypersensitivity reaction
Type II
Antibodies that bind to cell-surface antigens causing cellular destruction, inflammation, and dysfunction is what type of hypersensitivity reaction?
Type II
Phagocytosis and/or activation of complement causing cellular destruction is what type of hypersensitivity reaction?
Type II
Antibody-dependent cellular cytotoxicity is what type of hypersensitivity reaction
Type II
Autoimmune hemolytic anemia is what type of hypersensitivity reaction
Type II
Immune thrombocytopenic purpura is what type of hypersensitivity reaction
Type II
Transfusion reactions are what type of hypersensitivity reaction
Type II
Hemolytic disease of the newborn is what type of hypersensitivity reaction
Type II
Binding of antibodies to cell surfaces causing activation of complement system and Fc receptor-mediated inflammation is what type of hypersensitivity reaction
Type II
Goodpasture syndrome, Rheumatic fever, and hyperacute transplant rejection are what type of hypersensitivity reactions
Type II
Antibodies binding to cell surface receptros causing abnormal blockade or activation of downstream process is what type of hypersensitivity reaction
Type II
Myesthenia gravis, Graves disease, and pemphigous vulgaris are what type of hypersensitivity reactions
Type II
Antigen-antibody-complement immune complex is what type of hypersensitivity reaction
Type III
SLE, Polyarteritis nodosa, Poststreptococcal glomerulonephritis are what type of hypersensitivity reactions
Type III
Type III hypersensitivity reactions involve what type of cells?
Antigen-antibody-complement complex that attracts neutrophils that release lysosomal enzymes
Arthus reaction are caused by what?
Antigen-antibody complexes
Immune complex disease in which antibodies to foreign proteins are produced and can take 5-10 days
Serum sickness
Fever, urticaria, arthralgia, proteinuria, lymphadenopathy after antigen exposure is seen in what?
Serum sickness, a type III hypersensitivity reaction
Edema, necrosis, and activation of complement after an intradermal injection causing and immune-complex formation is seen in what?
Arthus reaction, at type III hypersensitivity reaction
Immune complexes deposit in membranes that fix complement is seen in what?
Serum sickness, a type III hypersensitivity reaction
Type IV hypersensitivity reaction involving direct cell cytotoxicity involves what cell types?
CD8+ cytotoxic T-cells
Delayed-type IV hypersensitivity reaction involves what cell types?
CD4+ helper T-cells
Mechanism of macrophage activation in delayed-type IV hypersensitivity reaction
CD4+ helper T-cells encounter antigen, release cytokines causing inflammation and macrophage activation
Hypersensitivity reaction that does not involve antibodies
Type IV
Which hypersensitivy reactions involve antibodies
Type I, II, III
Diabetes mellitus type I is what type of hypersensitivy reaction
Type IV, direct cell cytotoxicity
Contact dermatitis like poisin ivy or nickel allergy is what type of hypersensitivy reaction
Type IV, delayed
Graft-vs-host disease is what type of hypersensitivy reaction
Type IV, delayed
