PAS - Observational Epidemiology Studies Flashcards
outcome - define?
the disease or occurrence of event being studied - any measurable change in health status
exposure factors - define?
any factor that may affect the risk of developing a disease or health outcome
e.g. environmental, lifestyle, biological agents, specific behaviours
risk factor - define?
characteristic or exposure that increases the likelihood of developing a disease or health outcome
e.g. smoking, diet, age, genetic pre-disposition = modifiable & non-modifiable
types of observational studies?
cohort study
case-control study
cross-sectional study
cohort study - study design?
participants who do not have the outcome at baseline are followed over time to see ho develops the outcome of interest
helps estimate the incidence of the outcome
prospective cohort study?
follows a cohort of individuals over time, starting before they develop the outcome of interest
risk factor of interest is defined beforehand, and participants are classified as ‘exposed’ or
‘unexposed’ regarding the chosen risk factor
other risk factors/ confounding variables collected at base-line and during follow-up
at the end of the follow-up period, interest assess the manifestation of the outcome of interest in regards to their exposure status
retrospective cohort study?
existing data from historical records used to follow a cohort from the past to the present
categorises participants by past exposure to a pre-defined risk factor and assessing current outcomes/ outcomes that have already occurred
confounder - define? effect of a confounder on study data?
a variable which is associated with the exposure of interest, and independently associated with the risk of developing the outcome
can lead to an under/ over-estimation of a real association between exposure & outcome
how can we deal with confounders in cohort studies?
prospective cohort studies allow pre-specified confounders of interest to be studied
difficult with historical/ retrospective cohort studies as record may lack the information on the confounder of interest
adjust statistical models, or analyse results stratified by the confounder
how can risk ration be used as measures of association from cohort studies?
risk ratio = risk of disease occurring in an exposed group / unexposed group
RR = 1 - no difference between groups
RR > 1 - increased risk in exposed group
confidence intervals can be applied - i.e. a range within which the true population relative risk is expected to lie with a 95% degree of certainty with a 95% CL
difference between relative and absolute risk?
relative risk = useful for understanding the strength of the relationship between exposure and outcome
absolute risk = clearer picture of the actual chance of a risk happening and its reduction, more meaningful for healthcare decisions
i.e.
absolute risk = AR(control) - AR(treatment) = X%
relative risk = AR(treatment)/ AR(control) = X (ratio below 1 means lower risk in treatment group)
advantages of cohort studies?
exposure measured before disease - reduces potential bias
multiple outcomes/ diseases can be studied for any one exposure
incidence of disease can be measured in exposed vs unexposed groups
disadvantages of cohort studies?
slow, expensive, complex
need large numbers - harder with rarer diseases/ rarer outcomes
collection of data may alter behaviour
losses to follow-up = can introduce bias
case-control study - define?
compares individuals with the outcome of interest (cases) to those without the outcome (controls)
retrospectively assesses and compares their exposures to potential risk factors - starts with the outcome and looks back in time at exposures
how to deal with confounders in case-control studies?
collect information on potential confounders and adjust for them at the analysis stage
take cofounder into account at the design stage by matching (during case-control matches)
- but over-matching can introduce bias, with introducing more ocnfoudners and trying to match each one