Parvoviridae Flashcards
Replication and site of inclusion bodies for parvo?
Replication and large IBs in the NUCLEUS
Name the two viruses that are non enveloped, ssDNA, and are small as hell
Parvoviridae and Circoviridae
T/F: Parvovirus can replicate in stationary cells
False. Parvo CANNOT replicate in stationary cells as it relies on actively dividing cells
T/F: Feline panleukopenia is AKA Feline distemper or feline infectious enteritis
True.
Etiology: Feline parvovirus. Highly contageous, often fatal dz of cats; severe in kittens
T/F: Cats can shed the virus in their urine/feces for a max of 6 weeks after recovery
True.
3 Transmissions of feline panleukopenia are
- oro-nasally by exposure to infected animals (feces, secretions, fomites)
- in utero transmission
- mechanical by flies
The hallmark of Feline panleukopenia is
destruction of all WBC elements
Incubation of FPV?
2-10 days
most common in kittens 3-5 months old
Clinical signs of FPV?
fever, depression, anorexia, vomiting, profuse, persistent and frequent bloody diarrhea, DIC, dehydration
How do you detect FPV?
- fecal viral antigen testing using immunochromatographic test kid
- ELISA
- Hemagglutination
prego cats, sick cats, kittens <4weeks, immunosuppressed cats should not be given this type of vaccine for FPV
Attenuated (modified) live vaccine (MLV)
This is one of the most common infectious dz of dogs
Canine parvovirus 2 (CPV-2)
T/F: CPV-2 is highly contagious and very stable in environment
True.
Resistant to many detergents/disinfectants
can persist indoors @ room temp for at least 2 months.
Modes of transmission of Canine Parvovirus 2
- oro-nasal to contaminated feces
- in utero
- contact w/ contaminated fomites
canine parvovirus 2 leads to
Enteritis, myocarditis, panleukopenia and cerebellar hypoplasia
*Similar to FPV
T/F: antibody detection (seriology) is the best method to test canine parvo
False. Not the best method b/c most dogs are vaccinated or have been previously exposed to CPV.
Nucleic acid detection using PCR is better
In pregnant dogs or colostrum deprived pups, what type of vaccine is best?
inactivated is best (b/c of potential damage to myocardial or cerebellar cells)
What is oseltamivir (Tamiflu) used for?
Tx of canine parvoviral enteritis
What the hell is SMEDI?
Still birth
Mummification
Embryonic Death
Infertility
What does porcine parvo cause?
reproductive failure in swine throughout the world
Transmission of pig parvo?
- Oronasal in non immune prego sow
- transplacental transmission
- Venereal transmission possible (boars shed virus in semen)
How long does it take for the maternal infection of porcine parvo to reach the fetus? What is so special about the transplacental infection?
15 days :(
- Because each fetus has a separate placenta, not all are infected at the same time*
- hence death at different stages of pregnancy is typical of PPV infections
What is the hallmark of PPV?
Increase in mummified fetuses after a normal gestation period
T/F: abortions are common in PPV
False! Abortions are uncommon!
Will a late fetus (> 70 days to term) survive PPV?
frequently develop lesions but also mount an immune response usually survive in utero
Hooray! Save the pigs!
T/F: ebryo/fetus (<30 days) infected w/ PPV dies, is reabsorbed and the dam may return to estrus
True
T/F: Like most parvoviruses, PPV can cause persistent infection with constant shedding of virus.
False! UNLIKE most parvoviruses, PPV can cause persistent infection w/ PERIODICAL shedding of a virus
