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Microbiology 2nd Sem Midterm > Parvo Virus, Papilloma And Polyoma Virus > Flashcards

Parvo Virus, Papilloma And Polyoma Virus Flashcards

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1
Q

Parvovirus

Characteristics

A

Icosahedral capsid
SS DNA
Naked
Non envelopd

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2
Q

Parvovirus

Major capsid protein

A

Non structural protein requires for replication

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3
Q

Parvovirus

Replicates only during the

A

Stationary phase

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4
Q

Parvovirus

Requires helper virus

A

Adenovirus

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5
Q

Parvovirus

Causes infection in humans

A

B19 virus

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6
Q

Parvovirus

Classification

A
  1. Parvoviridae

2. Desoviridae

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7
Q

Parvovirus

Parvoviridae

A

Erthythrovirus
Bocavirus
Dependovirus

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8
Q

Parvovirus

Erthythrovirus

A

Parvovirus B19 type 1
Strain k71 type 2
Strain v9 type 3

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9
Q

Parvovirus

defective virus that is an adeno-associated virus

A

Dependovirus

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10
Q

Parvovirus

Infect the insects

A

Desoviridae

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11
Q

B19

Cellular receptor

A

Blood group B antigen

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12
Q

B19

Erythroblastosis in the bone marrow

A

Aplastic anemia

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13
Q

B19

Endothelial cells on the blood vessels

A

Rash

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14
Q

Parvovirus B19

Mode of transmission

A 
Respiratory and oral secretions 
Blood transfusion 
Transplacental
Human ar only natural reservoir
No virus excretion in the urine
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15
Q

Parvovirus B19

Targets the

A

Immature cells in the erythroid lineage

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16
Q

Parvovirus B19

Major site of replication are in the

A

Bone marrow
Fetal liver
Some blood vessels

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17
Q

Parvovirus B19

Replication can cause

A

Death

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18
Q

Parvovirus B19

Syndromes involved

A

Erythema infectiosum/ 5th disease
Transient aplastic crisis
Pure red cell aplasia
Hydrops fetalis

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19
Q

Erythema infectiosum/ 5th disease

Including

A

Rosella rubella
Rubeolla
Varicella

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20
Q

Erythema infectiosum/ 5th disease

Occurs in

A

Early school age

Adults

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21
Q

Erythema infectiosum/ 5th disease

Ip

A

1-2 weeks

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22
Q

Erythema infectiosum/ 5th disease

Most probable site of viral shedding

A

Pharynx

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23
Q

Erythema infectiosum/ 5th disease

Contagious stage

A

Lytic stage

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24
Q

Erythema infectiosum/ 5th disease

Highest titter

A

Respiratory

Oral secretions

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25
Q

Erythema infectiosum/ 5th disease

Enters through the respiratory tract then spreads to _________ stopping of RBC production due to viral killing of erythroid series

A

Bone marrow - adult

Fetal liver - children

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26
Q

Erythema infectiosum/ 5th disease

Viremia

A

1 week after infection

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27
Q

Erythema infectiosum/ 5th disease

Pathogenesis

A 
Respiratory tract
Bone marrow
Stop RBC 
Viremia
Contagious stage
Persist 5 days
Present in nasal washes and gargle specimen
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28
Q

Erythema infectiosum/ 5th disease

2nd stage of illness

A 
Immunologic stage
Appearance of antibodies
Resolution of disease
Erythematous
Rash and arthralgia
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29
Q

Appearance of B 19 virus specific

A

Anti IgM

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30
Q

Erythema infectiosum/ 5th disease

Generalized erythematous rash most prominent in the face

A

Cutaneous rash or slapped cheek

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31
Q

Erythema infectiosum/ 5th disease

Arthralgia

A

Hands and knees

Adult

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32
Q

Transient aplastic crisis

Occur in patient with

A

Chronic hemolytic anemia

After bone marrow transplantation

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33
Q

Transient aplastic crisis

Only in patients with hemolytic anemia

A

Abrupt cessation of RBC synthesis

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34
Q

Persistent infection and chronic anemia

Immunocompromised patient

A

Pure red cell aphasia

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35
Q

Fetus is affected

Result of severe fetal anemia, especially in 2nd trimester

A

Hydrops fetalis

Fetal death before 20th week of pregnancy

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36
Q

Hydrops fetalis

A

No congenital abnormalities because the blood is the one affected

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37
Q

Prevalent in children with acute wheezing

Often found in mixed infections with other viruses

A

Human Bocavirus respiratory infection

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38
Q

Human Bocavirus respiratory infection

Pathogenesis

A

Unknown

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39
Q

Human Bocavirus respiratory infection

MOT

A

Respiratory route

Also detect in stool and serum samples

40
Q

Parvovirus diagnosis

Most sensitive, in situ hybridization of fixed tissues

A

PCR

41
Q

Parvovirus diagnosis

Serology

A

B19 IgM antibody

Present 2-3 months after infection

42
Q

Parvovirus treatment

5th disease

A

Symptomatic treatment

43
Q

Parvovirus treatment

Transient aplastic crisis

A

Symptomatic

Blood transfusion

44
Q

Parvovirus treatment

For immunocompromised and those with anemia

A

Immunoglobulin preparations containing antibodies

45
Q

Parvovirus treatment

Vaccine

A

No vaccine available

46
Q

Papovavirus

Old classification and does not exist

2 families

A

Papilloma virus

Polyomavirus

47
Q

Capable of causing lytic, chronic, latent, and transforming infection depending on host cell

A

Papovavirus

48
Q

Papovavirus

Morphology

A

Small
Icosahedral capsid
Non enveloped
DS DNA

49
Q

Papovavirus

Encode proteins that promote

A

Cell growth
Lytic viral replications
Permissive cell type
Oncogenically transformed non permissive cell type

50
Q

Papovavirus

Stimulate cell growth which facilitate replication of the viral genome
Codes for no structural protein

A

Early Genes ( E1-E7)

51
Q

Papovavirus

example of early gene

A

BT1
BT2
BT3

52
Q

Papovavirus

Viral attachment portein
Codes for structural protein

A

Late genes (L1 and L2)

53
Q

Human Papilloma virus

A

Former member of the papoviridae

54
Q

Human Papilloma virus

Characteristics

A

Double stranded circular CAN
Icosahedral
Naked

55
Q

Human Papilloma virus

Oncogenic

A

E6 and E7 oncoproteins

56
Q

Human Papilloma virus

Do not grow in

A

Cell cultures

57
Q

Human Papilloma virus

Capsomeres form

A

Regular pointed star shaped head

58
Q

Human Papilloma virus

Have defined tissue tropism

A

Epithelial cells of skin and mucous membrane

59
Q

Human Papilloma virus

Result mutation and stimulation of nuclear factors to chromosomal aberration

A

E7 protein to p105RB (retinoblastoma)

60
Q

Human Papilloma virus

Encode early 7 genes and late 2 genes

A

E6 protein to p53

61
Q

Human Papilloma virus

100 types of papilloma virus that are grouped into

A

1-16

62
Q

Human Papilloma virus

Lytic infections

A

Permissive cells

63
Q

Human Papilloma virus

Abortive, latent, persistent or immortalizing infections that can transform the cell into cancer

A

Non-permissive cells

64
Q

Human Papilloma virus

Important characteristics

A

Stimulate DNA synthesis
Tissue tropism
Significant cause of human cancer
Viral oncoproteins

65
Q

Human Papilloma virus

Classifications

A 
Alpha
Beta
Gamma
Mupa
Napa
66
Q

Human Papilloma virus

HPV type of plantar warts

A

1

Benign

67
Q

Human Papilloma virus

Type of common skin warts

A

2,4,27,57

Benign

68
Q

Human Papilloma virus

Type of HPV cutaneous lesions

A

3,10,28,29,60,76,78

Low

69
Q

Human Papilloma virus

Epidermodysplasia verruciformis

A 
5
8
9
12
17
20
36
47

Mostly benign

70
Q

Human Papilloma virus

Hand warts of butchers

A

7

Low

71
Q

Human Papilloma virus

Anogenital warts

A

6,11,40,42-44,54,61,70,72,81

Low

72
Q

Human Papilloma virus

Infect and replicate in the

A 
Squamous epithelium (warts)
Mucous membranes (papilloma virus)
73
Q

Human Papilloma virus

Enlarged keratinocytes with haloes around shrunken nuclei

A

Koilocytes

74
Q

Human Papilloma virus

Infection may regress spontaneously but

A

Recurrence is common

75
Q

Human Papilloma virus

Important in the resolution of and control of the infection

A

Innate immunity and CMI

76
Q

Human Papilloma virus

MOT

A

Direct contact- due to shedding
Minor skin abrasions
Sexual contact - anogenital warts

77
Q

Human Papilloma virus

Mole and warts

A

Mole- smooth surfaces

Warts- rough

78
Q

Human Papilloma virus

Skin warts

A

1-4

79
Q

Human Papilloma virus

Laryngeal papilloma

A

6 and 11

80
Q

Human Papilloma virus

Anogenital warts

A

6&11

Condylomata acuminata

81
Q

Human Papilloma virus

Cervical, orophanyngeal and penile Ca

A

Worst type of warts

16 and 18

82
Q

Human Papilloma virus
It takes 3-4 months before a wart can develop
Once you have a warts, faster spread

A

Epidermodysplasia verruciformis

83
Q

Human Papilloma virus

Usually in the face and body

A

Flat warts

84
Q

Human Papilloma virus

Domed shape warts
Hands and feet

A

Common warts

85
Q

Human Papilloma virus

Skin tags

A

Cutaneous lesion

86
Q

Human Papilloma virus

Usually malignant
Sun exposure
30-40
Mixed type HPV
Very rare autosomal recessive
A

Epidermidis plasma verruciformis

87
Q

Human Papilloma virus

Laboratory diagnosis

A

Cytology
DNA molecular probe
PCR
Southern blot

88
Q

Human Papilloma virus

Treatment

Used for common warts

A

Surgical excision

89
Q

Human Papilloma virus

Treatment

For flat warts

A

Application of caustic agents
Electro cautery
Cryosurgery

90
Q

Human Papilloma virus

Treatment

Drugs

A

Imiquimod
Topical idoxuridine
Systemic or intralesional alpha interferon
Cidofovir

91
Q

Human Papilloma virus

Prevention

From HPV 6,11,16 and 18

A

Quadrivalent vaccine

92
Q

Human Papilloma virus

Prevention

From type 16 and 18 for high risk patient

A

Bivalent

93
Q

Human Papilloma virus

Vaccine given as early ____ before they become sexually active

A

11

94
Q

Yung polyoma virus, wala pang BS

A

Kpag may time pa gawan, kung wala na, dun mo na lang aralin,

95
Q

Smallest and simplest of all DNA viruses

A

Parvovirus

Microbiology 2nd Sem Midterm (5 decks)

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