Corona Virus

Question 1

Structure and replication

Answer 1

Enveloped virions

Longest (+) RNA

Question 2

Glycoproteins on the surface of the envelope

Answer 2

Club shape projections

Halo (corona)

Question 3

Corona form of glycoproteins

Answer 3

GIT and spread by the fecal oral route

Question 4

Large RNA + N protein

Answer 4

Helical nucleo capsid

Question 5

Protein synthesis

Answer 5

Same to toga virus

Has 2 phases

Question 6

Responsible for mediating viral attachment and membrane fusion

Answer 6

E2 glycoprotein

Question 7

Target of neutralizing antibodies

Answer 7

E2 glycoprotein

Question 8

Transmembrane matrix protein

Answer 8

E1 glycoprotein

Question 9

Corona disrupt the function of

Answer 9

Ciliated epithelial cells

Question 10

Localized to URT because of

Answer 10

Optimum temperature for viral growth

Question 11

Spread

Answer 11

Aerosols

Large droplets

Question 12

Long incubation period than rhinovirus

Answer 12

3 days

Question 13

How many percent of URTI cause by corona

Answer 13

10-15%

Question 14

Also seen in.

Answer 14

Diarrhea
Gastroenteritis
Neonatal necrotizing enterocolitis

Question 15

The virus infects and kills the

Answer 15

Alveolar epithelium

Question 16

Mortality of SARS

Answer 16

10%

Question 17

Aside from respiratory droplets, it is also present in

Answer 17

Sweat
Urine
Feces

Question 18

Unique feature of corona viruses

Answer 18

Medium sized virions
Corona like appearance
SS (+) RNA genome
Enclosed envelope containing E2, E2 and N

Question 19

Virus assemble at the

Answer 19

RER

Question 20

Method of choice for corona virus is

Answer 20

Viral RNA genome in respiratory and stool samples by RT-PCR

Question 21

Isolation of SARS COV requires

Answer 21

BSL3

Question 22

Isolation of SARS COV requires

Answer 22

BSL3

Question 23

Isolation of suspected SARS COV

Answer 23

BSL2

Question 24

Used to evaluate acute and convalescent sera

Answer 24

ELISA

Question 25

To detect corona virus like particles in stool specimens

Answer 25

Electron microscopy

Question 26

2 serotypes

Answer 26

229E

OC43

Question 27

Receptor for SARS Co-V on surface of respiratory tract epithelium cells:

Answer 27

ACE2

Question 28

Viral attachment protein

Answer 28

E2

Question 29

Matrix protein

Answer 29

E1

Question 30

Nucleo capsid protein

Answer 30

N

Question 31

Virus absorb to cells via its surface spikes

Answer 31

Hemagglutinin

Question 32

2 phases

Answer 32

1. Produces RNA polymerase

2. From - sense RNA template yields structural and no structural proteins

Question 33

Replication occurs in

Answer 33

Cytoplasm

Question 34

Infects upper respiratory tract

Answer 34

OLD COV

Question 35

Infects lower respiratory tract

Answer 35

New COV

Question 36

SARS COV

Natural reservoir

Answer 36

Horse bat

Question 37

SARS CoV

Intermediate host

Answer 37

Civet cat

Question 38

CXR

Answer 38

Interstitial ground glass infiltrates without cavitation

Question 39

CBC

Answer 39

Leucopenia

Thrombocytopenia

Question 40

Can grow in

Answer 40

Human embryonic trachea organ culture

Question 41

A combination of ______ and _____ has been tried in the treatment of life threatening cases of SARS, but their efficacy is uncertain

Answer 41

Ribavirin

Steroids

Question 42

New SARS like

Answer 42

Novel corona virus (2012)

Middle East respiratory syndrome (2013)

Question 43

2 nd most prevalent cause of common colds

Answer 43

Corona virus

1st is rhinovirus