Part VIII

Question 1

SPECT is dep. on sternal photon’s physical interactions [..]

Answer 1

absorption, attenuation, scattering

Question 2

other name for SPECT

Answer 2

Scintigraphy

Question 3

SPECT Process

Answer 3

1. Intro RP into pt’s body
2. Undergo decay in poi
3. Emit y rad
   4.Y rad detected by collimator (II y rad will only be captured to prevent misregistration)
   5.NaI-Tl convert energy to light
4. Light collected by PMT converted into electrons
5. converted into x and y signals
6. PHA - decode energy of emitted photon

Question 4

Properties of RN

Answer 4

1. Tp1/2 = few hours
2. decay to stable d
3. emit y ray
   4.50-300 keV Y RAY
4. monoenergetic (PHA eliminate scatter)
5. easily n firmly attach to pharmaceutical @ room temp
6. v. high specific act
7. v. low toxicity

Question 5

T/F imaging done as close as possible to body to minimize scatter

Answer 5

T

Question 6

2 MODES OF GAMMA RAY HEADS

Answer 6

Continuous Acquisition - in motion
Step and Shoot -stop @ defined angles

Question 7

SPECT applications

Answer 7

brain
cardiac
gastric
hepatobiliary
pulmonary
thyroid
renal
whole-body bone

Question 8

3 things [brain SPECT]

Answer 8

1. Areas of brain that work well
2. Areas that are underactive
3. Areas that are overactive

Question 9

brain SPECT conditions

Answer 9

Alzheimer’s disease
Dementia
Stroke compartment
Tumours

Question 10

2 Types of Brain SPECT

Answer 10

Hydrophilic Compounds
Lipophilic Compounds

Question 11

RP cross the abnormal BBB and localize at pathologic sites and are not normal

Answer 11

hydrophilic compounds

Question 12

RP cross normal BBB and localize in normal brain cells

Answer 12

Lipophilic Compounds

Question 13

Brain SPECT [protocol]

Answer 13

360 deg camera rotation w/ 64x64x8 matrix

Question 14

study of csf flow

Answer 14

RN Cisternography

Question 15

[RN Cisternography] RP injected to [..]

Answer 15

subarachnoid space at level of L2-L3 vertebrae

Question 16

[RN Cisternography] RPs commonly used

Answer 16

99Tc pertechnetate
99Tc DTPA or glucoheptonate (GHP)
99Tc HMPAO

Question 17

[RN Cisternography] newer gen RP

Answer 17

123-I-IMP
123-I-HIPDM
201 Tl-DDC

Question 18

Evaluated heart’s blood supply

Answer 18

Myocardial Perfusion

Question 19

[Myocardial Perfusion] other names

Answer 19

Cardiac Stress-rest test or MPI

Question 20

Cardiac Stress-Rest Test Process

Answer 20

1. Pt jogs -few min
2. intensity increases every 3 min to induce max stress
3. ECG-monitor heart rate
4. RP-IV shortly after exercise stops

Question 21

[Myocardial Perfusion] evaluate

Answer 21

myocardial ischemia - obstruction of blood flow in heart
myocardial infarction - caused by heart attack

Question 22

[Myocardial Perfusion] protocol

Answer 22

180 deg, 64x64 matrix size

Question 23

[Myocardial Perfusion] common RN

Answer 23

201 Tl
99m Tc Sestamibi