Handout

Question 1

1st manmade elemenet

Answer 1

Tc99m

Question 2

[yr] technetos meaning artificial, 21 isotopes

Answer 2

1946

Question 3

Tc99m Importance

FESMEA

Answer 3

favorable biodistrib
excretion charac
short physical h
monoenergetic
easily combined w/ RP
can be used alone

Question 4

[Oral] 2 Processes Tc99m is absorbed from stomach and upper duodenum

Answer 4

1. Simple diffusion - GIT cells to get to bloodstream via interstitial fluid
2. Active transport - pass thru lumen - gastric cells lining to bloodstream

Question 5

[time] Tc99m will be absorbed after oral or indirect process

Answer 5

30m

Question 6

[%] pertechnetate that bind w/ serum protein; [%] excreted

Answer 6

70-80%
20-30%

Question 7

valence state of Tc in Tc04

Answer 7

+7 valence state

Question 8

+7 valence first into in 1966 for hepatic imaging

Answer 8

Tc99m sulfur colloid

Question 9

Tc99m prepared from commercially avail kits that contain:

Answer 9

sodium thiosulfate, phosphoric or hydrochloric acid, gelatin, buffer

Question 10

sodium thiosulfate and gelatin purpose

Answer 10

added to an acidified solution of Tc04

Question 11

Tc99m SC mechanism of action

Answer 11

phagocytosis (RES cells engulf colloidal particles)

Question 12

Tc99m SC imaging

Answer 12

gastric emptying
liver
spleen
bone marrow
lymphoscintigraphy

Question 13

common bone agents:

Answer 13

Tc99m HMDP and Tc99m MDP

Question 14

Tc99m HDMP and Tc99mMDP mechanism of uptake

Answer 14

adsorption on the mineral phase