Part 17: Gonadal Hormones Flashcards
the gonadal hormones are also known as ____
sex hormones
t/f sex hormones are involved in more than just reproduction
t
LH and FSH are secreted by the ____ gland to act on the ___ and ___
pituitary; testes & ovaries
stimulation of ovaries & testes by LH and FSH causes them to release ___
estrogens and androgens
sex hormones exist in a ___ feedback system
negative
androgens and estrogens cause negative feedback by looping back to the ___ and ___ glands
pituitary and hypothalamus
the frequency of ____ from the hypothalamus detrmines which pituitray hormone is released
pulsatile release of gonadotropin releasing hormone
what releases GnRH?
hypothalamus
what releases LH and FSH?
pituitary gland
what is the role of LH?
androgen release, ovulation
what is the role of FSH?
follicle development & spermatogenesis
which hormone will be released by pituitary if there is a high frequency of GnRH release from the hypothalamus?
LH
which hormone will be released by pituitary if there is a low frequency of GnRH release from the hypothalamus?
FSH
which hormones are released from the pituitary if there is constant release of GnRH from the hypothalamus?
neither FSH or LH
give 2 examples of what synthetic GnRH can be used to treat
infertility; some types of hormone sensitive cancer
what is the main role of FSH in males?
starting puberty and sperm maturation
____ is the primary hormone that stimulate the making of testosterone
LH
where is testosterone made?
Leydig cells of the testes
testosterone is made from ___
cholesterol
testosterone circulates in the blood by being bound to ___ protein
sex hormone binding globulin (SHBG)
testosterone binds to ___ receptors
intracellular androgen receptors
once inside target cells, testosterone is converted to ___ by ___ enzymes
dihydrotesterone (DHT); 5-alpha reductases
which is a higher potency agonist at androgen receptors, testosterone, or DHT?
DHT
the activated androgen-receptor complex is translocated to the ____ where it modifies gene ___ and ___ synthesis
nucleus, transcription; protein synthesis
t/f many of the androgenic effects we often associate with testosterone are actually caused by DHT
t
which androgen is responsible for the development of male secondary sex characteristics?
DHT
testosterone is important in early development and throughout life it is involved in the production and maintenance of ___, ___ , __and ___
muscle mass; red blood cells; bones; hair growth
testosterone can also be metabolized by CYP19 (aromatase) into ___
estradiol
the estrogens made from testosterone is important for ___ in males
bond density
the levels of estrogen in males is typically ____ (high or low)
low
t/f aromatase enzymes are expressed in fat cells, so obese men can express more estrogen and a decrease in testosterone
t
what are the 2 categories testosterone modulation falls into?
replacement or suppression therapy
androgen ____ therapy is used for low T syndrome
replacement
androgen ____ therapy is used for performance enhancement
replacement
androgen ____ therapy is used for treatment of prostate enlargement
suppression
androgen ____ therapy is used for treatment of hormone sensitive prostate cancer
suppression
what is low T syndrome?
circulating levels of testosterone are insufficient to maintain normal physiologic roles of androgens
t/f testosterone levels dcline with age
t
what are some of the symptoms of low T?
low sex drive, fatigue, hair loss, reduced muscle mass
t/f replacing testosterone can effectively manage low T symptoms
t
t/f the lipophilicity of steroid hormones make it possible to administer them transdermally
t
what are the benefits of transdermal testosterone?
slow release, easy, avoids 1st pass metabolism
what is a major downfall of oral testosterone treatment?
most will be metabolized before reaching systemic circulation
how is testosterone for performance typically administered?
high dose my IM injection
why is testosterone for performance typically given IM?
to target the muscle they want to grow and avoids 1st pass metabolism
what is Androderm?
testosterone transdermal patch
t/f androgens are involved in prostate enlargement
t
what is benign prostatic hyperplasia (BPH)?
a benign prostate enlargement
what is a common symptoms of enlarged prostate?
urinary retention
why does enlarged prostate cause urinary retention?
obstruction of the urethra
does prostate cancer have a high level of metastasis?
yes
ketoconazole and spironolactone are anti-androgens that work by what way?
inhibit testosterone biosynthesis
what is a concern when usifg ketoconazole to inhibit testosterone synthesis?
a CYP3A4 inhibitor which can lead to a lot of interactions
why are ketoconazole and spironolactone not commonly used as androgen suppressors?
they both have other systemic effects and there are drugs that are more specific to target androgen production