Chapter 14: Parkinson's Disease Flashcards
the initiation and termination of movement is controlled by neural circuits in the ___
basal ganglia
many movement disorders have been attributed to disturbances in the ___
basal ganglia
the basic circuitry of the basal ganglia involves 3 interacting neuronal loops that include the ___, ___ and ___
cortex, thalamus, basal ganglia themselves s
balanced signalling between the ___ and ___ pathways of the basal ganglia circuits is what allows for smooth, coordinated muscle movement
direct and indirect
when any part of the basal ganglia circuit becomes disturbed, movements can become ___
jerky, uncoordinated and hard to control
___ is an essential regulatory component of the basal ganglia circuit
dopamine
Parkinson’s disease is a ___ disease
progressive neurodegenerative
what are the hallmark symptoms of Parkinson’s disease?
motor symptoms: rigidity, bradykinesia (slowness of movement and difficulty starting the movement), tremor
what are some cognitive symptoms of Parkinson’s that can. occur as the diseases progresses?
personality changes, anxiety, depression, confusion, cognitive impairment, ANS dysfunction
symptoms of Parkinson’s occur due to changes in ___
neuronal signalling in several regions of the brain
what is an ANS functions that may be distributed by Parkinson’s?
blood pressure
in many parts of the brain there is a balancing between what 2 NT?
dopamine and Ach
alternations in the neuronal circuits between the ___ and __ lead to motor symptoms that present in Parkinson’s
substantia nigra and striatum
dopamine and Ach signalling circuits travel ___ in many parts of the brain
together
Ach ___ GABA release and Dopamine ___ GABA release
increases; decreases
what 2 NT act to balance GABA release to control motor movements?
dopamine and Ach
in Parkinsons disease the dopaminergic neurons originating in the substantiated nigra begin to ___and ___(more/less) dopamine is released leading to imbalance of GABA that causes motor symptoms
degenerate; less
the therapeutic strategies to manage Parkinsons disease aim to restore the balance between ___ and __
dopamine and Ach
what are 2 strategies to rebalance Ach and DA in Parkinson’s?
increase DA signalling and decrease ach signalling
t/f anticholinergic drugs have been used in the past to treat Parkinson’s disease
t
Benzotriptine is an example of a ____ drug once used for Parkinson’s disease
anticholinergic
why are anticholinergic drugs not typically used in the treatment of Parkinson’s disease
they have an extensive array of systemic effects
what is the benefit and pitfall of targeting Ach GABA release for management of Parkinsons?
removes some muscle rigidity & helps tremors but does not tend to improve bradykinesia
which is the primary way to manage Parkinsons? Ach or DA management?
DA
what are the 3 ways to increase DA?
- add more
- decrease DA metabolsim
- activate DA receptors
where is dopamine made>
dopaminergic neurons
DA is made up of ___
tyrosine
___ is the immediate precursor to DA
L-Dopa (levodopa)
L-Dopa is a ____ converted to DA by the enzyme ___
amino acid; amino acid decarboxylase aka DOPA decarboxylase
the step of converting L-DOPA to DA is common to another pathway, with one more step, DA can become __
NE
metabolsim of DA occurs due to ___ and ___ enzyme which can be found in the CNS and periphery
monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT)
there are 5 subtypes of DA receptors, divided into 2 families, the ___ and ___ families
D1 and D2
the D1 family includes ___ and ___ receptors which are coupled to ___G proteins
D1 and D5; excitatory (Gs and Gq)
when Gs is activated it leads to an increase in ___ and when Gq is activated it leads to an increase in ___
cAMP; IP3 and DAG
the D2 family is coupled to ___ G proteins
inhibitory (Gi)
D2 receptors are expressed in the ___ and ___ of the brain and D3 receptors are highly expressed in the ____
substantia nigra and striatum; nucleus accumbens