Parkinsons

Question 1

Gold Standard Treatment of Parkinsons Disease

Answer 1

Levodopa, usually coupled with carbidopa, a peripheral decarboxylase inhibitor (PDI).

Question 2

How does Levodopa work?

Answer 2

Crosses the blood-brain-barrier and after entering the central nervous system, it is converted into dopamine by the enzyme aromatic L-amino acid decarboxylase, also known as DOPA decarboxylase.

Question 3

How does Carbidopa work?

Answer 3

Inhibits the decarboxylation of levodopa to dopamine in the systemic circulation, allowing for greater levodopa distribution into the central nervous system.

Question 4

Abnormal movement that is most closely associated with PD?

Answer 4

Resting Tremor

Question 5

PD gait type?

Answer 5

Festinating and shuffling gait

Question 6

TRAP in PD

Answer 6

Tremors, Rigidity, Akinesia(Brady) and Postural Instability (Shuffling gait with a stooped posture often with festination).

Question 7

PD, degeneration in which area of the brain?

Answer 7

Substantia nigra