Parkinson's Meds Flashcards
prototype for parkinsons disease
levadopa
goal for trt of parkinsons
minimize symptoms - improve daily life - not curative
s/s for trt of parkinsons
bradykinesia, postural instabilty
2 neurotransmitters involved in parkinsons
dopamine (deficit) and acetylcholine (excess)
drugs used for parkinsons increase dopamine, t or f
true
awkward movements in parkinsons are attributed to
excess of acetylcholine
how long does it take for levadopa to be effective
up to several months - stay with it
levadopa over time becomes less effective, t or f
true - shorten dose interval
how is levadopa given
po
s/e of levadopa
n/v - while subside over time, take with a carb so it doesn’t compete with protein
darkening of the urine
can speed up malignant melanoma
what do we want to avoid while taking levadopa
haldol (1st gen anti-psychotic)
protein (competes for absorption)
dopamine doesnt cross the
blood brain barrier - leva portion is a mechanism to cross the blood brain barrier
why is levadopa commonly paired with carbidopa
slows down metabolism of levadopa so that it could cross the blood-brain barrier for dopamine effect/benefit