Parkinson's Meds Flashcards

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1
Q

prototype for parkinsons disease

A

levadopa

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2
Q

goal for trt of parkinsons

A

minimize symptoms - improve daily life - not curative

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3
Q

s/s for trt of parkinsons

A

bradykinesia, postural instabilty

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4
Q

2 neurotransmitters involved in parkinsons

A

dopamine (deficit) and acetylcholine (excess)

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5
Q

drugs used for parkinsons increase dopamine, t or f

A

true

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6
Q

awkward movements in parkinsons are attributed to

A

excess of acetylcholine

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7
Q

how long does it take for levadopa to be effective

A

up to several months - stay with it

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8
Q

levadopa over time becomes less effective, t or f

A

true - shorten dose interval

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9
Q

how is levadopa given

A

po

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10
Q

s/e of levadopa

A

n/v - while subside over time, take with a carb so it doesn’t compete with protein
darkening of the urine
can speed up malignant melanoma

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11
Q

what do we want to avoid while taking levadopa

A

haldol (1st gen anti-psychotic)

protein (competes for absorption)

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12
Q

dopamine doesnt cross the

A

blood brain barrier - leva portion is a mechanism to cross the blood brain barrier

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13
Q

why is levadopa commonly paired with carbidopa

A

slows down metabolism of levadopa so that it could cross the blood-brain barrier for dopamine effect/benefit

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