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Final - Pharm - Neuro/Psych > Anti-depressants > Flashcards

Anti-depressants Flashcards

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1
Q

primary treatment for depression

A

antidepressants

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2
Q

5 classes of medication that treat depression

A

Selective serotonin reuptake inhibitors (SSRI’s)
Serotonin/norepinephrine reuptake inhibitors (SNRI’s)
Tricyclic antidepressants (TCA’s)
Monoamine oxidase inhibitors (MAOI’s)
Atypical antidepressants

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3
Q

how long does it take to see benefits of pharmacotherapy for depression

A

1-3 weeks, can take up to 12 weeks for a response

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4
Q

how long will pt. remain on med once in remission

A

4-9 months

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5
Q

best practice for prescribing antidepressants

A

start low and go slow

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6
Q

when discontinuing anti-depressant be sure to

A

taper or else pt. will get very sick

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7
Q

all antidepressants come with a black box warning, t or f

A

true - suicide risk

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8
Q

age related risks for suicide

A

18-24 increased risk for suicide
25-30 neutral effect
>30 decreased risk

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9
Q

most commonly prescribed anti-depressant

A

SSRI

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10
Q

prototype SSRI

A

Prozac

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11
Q

Prozac is commonly prescribed for these disorders

A

OCD, Bulimia, Premenstrual Dysphoric Disorder

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12
Q

SSRI adverse effects are considered low but include

A

weight gain and sexual dysfunction

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13
Q

prototype SNRI

A

Effexor

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14
Q

first line treatment for depression is an

A

SSRI

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15
Q

which drug class has fewer adverse effects SSRI or SNRI

A

SSRI

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16
Q

Effexor is commonly prescribed for these disorders

A

GAD - generalized anxiety disorder
major depression
social anxiety disorder

17
Q

how does Effexor work

A

blocks uptake of norepinephrine and serotonin

18
Q

s/e of Effexor

A

diastolic HTN - if known hx of HTN do not prescribe

19
Q

a serious reaction can occur with Effexor and MAOI’s, t or f

A

true - must wait 2 weeks in between the 2 meds

20
Q

tricyclic antidepressants are cardio toxic, t or f

A

true

21
Q

s/e of tricyclic antidepressants

A

dizziness (get up slowly),drowsiness, photophobia, blurred vision, dry eye, constipation, increased risk for seizures, hypomania, yawngasm, cardiotoxic

22
Q

tricyclic antidepressants are a good drug choice for these disorders

A

bipolar disorder and neuropathic pain

23
Q

composition of tricyclic antidepressants is similar to

A

phenothiazine’s

24
Q

how do tricyclic antidepressants work

A

blocks receptors for histamine and acetylcholine as well as serotonin and NE

25
Q

how often/when do you give tricyclic antidepressants

A

once a day at bedtime

26
Q

overdose with tricyclic antidepressants can be life threatening, t or f

A

true

27
Q

s/s of tricyclic antidepressant overdose

A

tachycardia and palpitations

28
Q

trt for tricyclic antidepressant overdose

A

charcoal with gastric lavage

propranolol

29
Q

*monoamine oxidase inhibitors and tyramine foods could cause this

A

hypertensive crisis

30
Q

how do monoamine oxidase inhibitors work

A

inactivates NE, serotonin and dopamine, increases neurotransmitters so pt. isn’t depressed

31
Q

what type of foods have tyramine in them

A

processed foods aged cheese Swiss, bleu, pepperoni, salami

32
Q

drug of choice for atypical depression

A

monoamine oxidase inhibitors

33
Q

s/e of MOAI

A

HTN, headache, tachy, n/v, confusion, sweating

34
Q

atypical antidepressant

A

Wellbutrin

35
Q

moa of Wellbutrin

A

stimulates appetite w/o weight gain; increases sex drive/pleasure

36
Q

what type of disorder is contraindicated w/Wellbutrin

A

eating disorders - likely to develop a seizure

37
Q

non-conventional drugs found to treat depression

A

ketamine - bolus IV
St. johns wort - interacts w/SSRI’s
SAMe

38
Q

MOA of SSRI (Prozac)

A

selective inhibition of serotonin uptake

CNS excitation

Final - Pharm - Neuro/Psych (11 decks)

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