Parkinson's Disease

Question 2

Define Parkinson’s Disease and its characteristic findings.

Answer 2

Question 3

What are the types of parkinson’s disease?

Answer 3

Question 4

What are the characteristic features of the following diseases:
1. Progressive supranuclear palsy

Answer 4

Question 5

What are the characteristic features of the following diseases:
1. Multiple systems atrophy

Answer 5

Question 6

What are the characteristic features of the following diseases:
1. Lewy body dementia

Answer 6

PD - parkinsonism then dementia
Lewy body - demetia then parkinsonism.

Question 7

What are the characteristic features of the following diseases:
1. cortico-basal degeneration

Answer 7

Question 8

Parkinson’s Disease is the 2nd most common neurodegenerative disorder after alzheimer’s disease.
What are some RFs for PD?

Answer 8

Question 9

In PD, where do ley bodies deposit?

Answer 9

Lewy bodies deposit in olfactory bulb, pontine tegmentum and enteric plexus

Question 10

Explain the pathophysiology of PD.

Answer 10

Lewy bodies deposit in olfactory bulb, pontine tegmentum and enteric plexus

Question 11

What are the first symptoms of parkinson’s disease?

Answer 11

Question 12

What is the REM sleep behaviour disorder in PD?

Answer 12

Question 13

List and describe the 4 main symptoms of PD.

Answer 13

Question 14

What are all the symptoms of parkinson’s disease? What other question would you ask the patient in the history?

Answer 14

Question 15

How would you assess the tremor in a PD patient?

Answer 15

Question 16

How would you assess the rigidity in a PD patient?

Answer 16

Question 17

How would you assess the bradykinesia in a PD patient?

Answer 17

Question 18

How would you assess the postural instability in a PD patient?

Answer 18

Question 19

How would you assess the functional status in a PD patient?

Answer 19

Question 20

Outline how you would perform an extrapyramidal system exam for parkinson’s disease.

Answer 20

Question 21

List some DDX for PD.

Answer 21

Question 22

What are the causes of acute deterioration in PD?

Answer 22

Question 23

How would you diagnose PD?

Answer 23

Question 24

What investigations would you order to rule out ddx of PD? What are the possible findings of these tests?

Answer 24

Question 25

How is the cognitive impairment in PD treated? How is cognitive impairment detected?

Answer 25

MMSE <24 - increased risk of cognitive impairment

Question 26

What investigations would you order to detect complications of PD? What are the possible findings of these tests?

Answer 26

Question 27

What are all your investigations for PD?

Answer 27

Question 28

What scale can be used to grade the severity of PD?

Answer 28

Question 29

Outline the acute management of PD.

Answer 29

Question 30

Outline the long term pharmacological management of PD including MOAs

Answer 30

Question 31

What are the SEs of sinemet, stalevo and madopar?

Answer 31

Question 32

WHat is the function of deep brain stimulation in PD?

Answer 32

Question 33

Outline the long term advanced therapies for PD including their route of administration.

Answer 33

Question 34

What is the management of levodopa induced dyskinesia?

Answer 34

Question 35

Outline the full management of PD.

Answer 35

Question 36

Define levodopa-induced dyskinesia.

Answer 36

Question 37

PD has a 77% chance of poor outcomes at 10yrs after dx. What are the complications of PD?

Answer 37