Neuromuscular Disorders Flashcards
Define the term neuromuscular disorders.
What is the mean age of onset of neuromuscular disorders?
What are the RFS for the development of neuromuscular disorders.
Describe the pathophysiology of neuromuscular disorders.
List the 4 types of neuromuscular disorders? which is the most common?
- Amyotrophic Lateral Sclerosis - most common
- Progressive Bulbar Palsy
- Progressive Muscular Atrophy
- Primary Lateral Sclerosis
Describe the features of ALS.
Describe the features of progressive bulbar palsy.
Describe the features of progressive muscular atrophy.
Describe the features of primary lateral sclerosis.
Symptoms of neuromuscular disorders can be separated into UMN, LMN, pseudobulbar, bulbar and respiratory symptoms.
What are the UMN symptoms?
Symptoms of neuromuscular disorders can be separated into UMN, general LMN, pseudobulbar, bulbar and respiratory symptoms.
What are the general LMN symptoms (not including the pseudobulbar/bulbar palsy symptoms)?
Symptoms of neuromuscular disorders can be separated into UMN, LMN, pseudobulbar, bulbar and respiratory symptoms.
What are the pseudobulbar symptoms?
Symptoms of neuromuscular disorders can be separated into UMN, LMN, pseudobulbar, bulbar and respiratory symptoms.
What are the bulbar symptoms?
Symptoms of neuromuscular disorders can be separated into UMN, LMN, pseudobulbar, bulbar and respiratory symptoms.
What are the respiratory symptoms?
List the symptoms of neuromuscular disorders.
Where does UMN become LMN?
What is the pathophysiology behind dysphagia in a UMN vs LMN lesion?
What is the pathophysiology behind uncoordinated movements in a UMN vs LMN lesion?
What is the pathophysiology behind falls in a UMN vs LMN lesion?
Are spasms UMN, LMN or both?
You are asked to perform a focused exam on a patient with a neuromuscular disorder. What exams will you do? What would you expect on general inspection?
you would also offer speech and swallow assessment
What cranial nerves are mostly affected by neuromuscular disorders?
You are asked to perform a focused exam on a patient with a neuromuscular disorder. What would you expect on cranial nerve exam?
You are asked to perform a focused exam on a patient with a neuromuscular disorder. What would you expect on motor exam?
weakness - decreased power and coordination.
+ gait - unsteady/ spastic gait vs flaccid gait
You are asked to perform a focused exam on a patient with a neuromuscular disorder. What would you expect on sensory exam?
List the ddx for neuromuscular disorders and state the differentiating features.
How would you diagnose a neuromuscular disorder?
IT IS A Dx OF EXCLUSION!!
List and justify the investigations you would order for a suspected neuromuscular disorder and state your expected findings.
The management of a patient with neuromuscular disorders require MDT input. Who would be involved in the MDT and what are their roles?
What is the disease - modifying drug used in the treatment of neuromuscular disorders? What is the MOA and the SEs? How is the drug monitored?
Outline the pharmacological management of neuromuscular disorders.
Outline the adjunctive/ surgical management of neuromuscular disorders.
What are the complications of neuromuscular disorders?
What is the average lifespan of a patient with neuromuscular disorders from dx?
What are 2 good and 1 poor prognostic factor of neuromuscular disorders?
