Parkinson's Disease

Question 1

Parkinson’s is an imbalance in what neurotransmitters

Answer 1

Too little Dopamine and too much acetylcholine

Question 2

Signs and symptoms of Parkinson’s

Answer 2

TRAP
Tremor, rigidity, akinesia, postural instability

Question 3

What drugs are examples of dopamine agonists for Parkinson’s disease?

Answer 3

Carbidopa/levodopa
pramipexole
ropinirole

Question 4

What are some food interactions with levodopa/carbidopa

Answer 4

High protein, High Vitamin B6 (green vegetables, bananas, legumes), Iron supplements

Question 5

what kind of hallucinations may occur with taking dopaminergic medications?

Answer 5

visual hallucinations and paranoia

Question 6

What drug can cause impulse control issues (gambling, shopping, binge eating) for Parkinson’s

Answer 6

Pramipexole and ropinirole

Question 7

What medication is a monoamine oxidase-B inhibitor

Answer 7

Selegiline
Oral form = Parkinson’s
Transdermal = antidepressant

Question 8

MOA of Selegiline

Answer 8

Prevents breakdown of dopamine

Question 9

Food and drug interaction with Selegiline

Answer 9

tyramine-rich foods (cheese, smoked/cured meats, figs, avocados, beer/wine, soy sauce)

Avoid other antidepressants and pseudoephedrine

Question 10

Anticholinergics for Parkinson’s

Answer 10

Benztropine and Trihexyphenidyl

Question 11

What are the common uses for Benztropine and Trihexyphenidyl

Answer 11

they can also treat EPS caused by antipsychotic drugs

Question 12

What is the MOA of Benztropine and Trihexyphenidyl

Answer 12

Decrease acetylcholine in the brain by blocking acetylcholine receptors

Question 13

What are some common side effects of Benztropine and Trihexyphenidyl?

Answer 13

anticholinergic effects: can’t see, pee, poop, spit

drowziness