Parkinson Drugs

Question 1

1.5 modules away from spring break…

Answer 1

Just saying.

Question 2

Levodopa/Carbidopa: class

Answer 2

Dopamine

Question 3

Levodopa/Carbidopa: MOA

Answer 3

Increase dopamine levels in CNS

Question 4

Levodopa/Carbidopa: indictaion

Answer 4

Parkinson’s disease

Question 5

Levodopa/Carbidopa: side effects

Answer 5

Early: N/V, anorexia, HOTN
Late: Dyskinesia, sleep attacks

Question 6

Levodopa/Carbidopa: contraindication

Answer 6

Renal/hepatic disease

Question 7

More than 50% of Pts on Levodpa/Carbidopa develop…

Answer 7

Motor fluctuations and dyskinesia

Question 8

Benztropine: class

Answer 8

Anticholinergic

Question 9

Benztropine: MOA

Answer 9

Ach receptor inhibition

Question 10

Benztropine: indication

Answer 10

PD, extrapyramidal sxs

Question 11

Benztropine: side effects

Answer 11

Dry mouth, urinary retention, blurred vision, temp insensitivity

Question 12

Benztropine: contraindication

Answer 12

Dementia, urinary retention, glaucoma

Question 13

There’s good new and bad news about Benztropine. What is it?

Answer 13

Good new: it decreases drooling and tremors…

Bad news: it doesn’t really help with bradykinesia, rigidity, or gait disturbances

Question 14

Amandatine: class

Answer 14

NMDA receptor antagonist

Question 15

Amantadine: MOA

Answer 15

Decreases Levodopa injury to NMDA receptos

Question 16

Amantadine: indictaion

Answer 16

Mild PD sxs

Question 17

Amantadine: side effects

Answer 17

Livedo reticularis, peripheral edema, orthostatic HOTN

Question 18

Amandtadine: contraindications

Answer 18

CKD

Question 19

In what population should Amantadine be avoided?

Answer 19

The elderly

Question 20

Eldepryl: class

Answer 20

MAO-B inhibitor

Question 21

Eldepryl: MOA

Answer 21

Inhibition of MAO-B enzyme results in increased available dopamine in CNS

Question 22

Eldepryl: indication

Answer 22

PD, depression

Question 23

Eldepryl: side effects

Answer 23

Dyskinesia, confusion, hallucinations

Question 24

Eldepryl: contraindication

Answer 24

Bipolar d/o, etoh

Question 25

What is the daily limit of Eldepryl?

Answer 25

10mg

Question 26

Requip: class

Answer 26

Dopamine agonist

Question 27

Requip: MOA

Answer 27

Stimulated D3 receptors directly

Question 28

Requip: indication

Answer 28

PD, restless leg syndrome

Question 29

Requip: side effect

Answer 29

OCD

Question 30

There are two different ways to use Requip. What are they?

Answer 30

Can be used initially as mono therapy. | Later in course, can be used as an add on to Levodopa.

Question 31

Comtan: class

Answer 31

COMT inhibitor

Question 32

Comtan: MOA

Answer 32

COMT enzyme inhibition result in increased [dopamine] in CNS

Question 33

Comtan: indication

Answer 33

PD - used in combo with Levodopa

Question 34

What's the good news and the bad news about Comtan?

Answer 34

Good news: Early on it will decrease Levodopa side effects. Bad news: That doesn't last forever.