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Neuro Pharm > MS Drugs > Flashcards

MS Drugs Flashcards

1
Q

Glatiramer Acetate: class

A

Glatiramir

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2
Q

Glatiramer Acetate: MOA

A

Decreases activation of T cells;

Activates Th2 cells

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3
Q

Glatiramer Acetate: indication

A

RRMS

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4
Q

Glatiramer Acetate: side effect

A

Chest tightness, dyspnea

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5
Q

Glatiramer Acetate: Route of admin

A

IM

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6
Q

Glatiramer Acetate reduces relapses by ____ per year

A

28%

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7
Q

Interferon B-1a: class

A

Beta Interferon

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8
Q

Interferon B-1a: MOA

A

Decreases Tcell activation
Promotes Th2 cells
Decreases microglial proliferation

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9
Q

Interferon B-1a: indication

A

RRMS

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10
Q

Interferon B-1a: side effect

A

flu-like sxs (60%)

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11
Q

Interferon B-1a: contraindication

A

Allergy to E.coli - derived products

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12
Q

What can happen after 18-24 months on Interferon B-1a?

A

Development of neutralizing Abs

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13
Q

Fingolimod: class

A

S1P receptor modulator

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14
Q

Fingolimod: MOA

A

Acts to keep T cells in lymphoid tissue

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15
Q

Fingolimod: indication

A

Relapsing forms of MS

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16
Q

Fingolimod: side efects

A

Bradycardia

17
Q

Fingolimod: contraindications

A

Lack of VZV immunity

18
Q

Fingolimod decreases circulating lymphoctes by ____ for up to _____ after it’s discontinued.

A

75%

2 months

19
Q

Natalizumab: class

A

Selective Adhesion-Molecule Inhibitor

20
Q

Natalizumab: MOA

A

Prevents lymphocyte migration into CNS

21
Q

Natalizumab: indication

A

Relapsing forms of MS

22
Q

Natalizumab: side efects

A

Progressive multifocal enecphalopathy

23
Q

Access of Natalizumab is restricted to whom?

A

TOUCH program participants

24
Q

Dimethyl Fumarate: class

A

Nrf2 Activator

25
Q

Dimethyl Fumarate: MOA

A

Unknown - but thought to arise from activation of anti-oxidative pathways

26
Q

Dimethyl Fumarate: indication

A

RRMS

27
Q

Dimethyl Fumarate: side effect

A

Progressive multifocal encephalopathy

28
Q

Dimethyl Fumarate: pregnancy class

A

Unknown - too new

29
Q

Dimethyl Fumarate reduces relapses by ___ per year

A

75%

30
Q

Baclofen: class

A

Antispasmotic

31
Q

Baclofen: MOA

A

GABA receptor agonist producing hyperpolarization and pre-synaptic inhibition

32
Q

Baclofen: indication

A

Muscle spasticity in MS and spinal cord lesions

33
Q

If you want to D/C Baclofen, how do you do it?

A

Down titrate slowly

34
Q

Dantrolene: class

A

Antispasmotic

35
Q

Dantrolene: MOA

A

Blocks RyR1 Ca++ channels in sarcoplasmic reticulum, esp rapid contraction fibers

36
Q

Dantrolene: indication

A

Upper motor neuron spasticity

Neuro Pharm (5 decks)

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