MS Drugs

Question 1

Glatiramer Acetate: class

Answer 1

Glatiramir

Question 2

Glatiramer Acetate: MOA

Answer 2

Decreases activation of T cells;

Activates Th2 cells

Question 3

Glatiramer Acetate: indication

Answer 3

RRMS

Question 4

Glatiramer Acetate: side effect

Answer 4

Chest tightness, dyspnea

Question 5

Glatiramer Acetate: Route of admin

Answer 5

IM

Question 6

Glatiramer Acetate reduces relapses by ____ per year

Answer 6

28%

Question 7

Interferon B-1a: class

Answer 7

Beta Interferon

Question 8

Interferon B-1a: MOA

Answer 8

Decreases Tcell activation
Promotes Th2 cells
Decreases microglial proliferation

Question 9

Interferon B-1a: indication

Answer 9

RRMS

Question 10

Interferon B-1a: side effect

Answer 10

flu-like sxs (60%)

Question 11

Interferon B-1a: contraindication

Answer 11

Allergy to E.coli - derived products

Question 12

What can happen after 18-24 months on Interferon B-1a?

Answer 12

Development of neutralizing Abs

Question 13

Fingolimod: class

Answer 13

S1P receptor modulator

Question 14

Fingolimod: MOA

Answer 14

Acts to keep T cells in lymphoid tissue

Question 15

Fingolimod: indication

Answer 15

Relapsing forms of MS

Question 16

Fingolimod: side efects

Answer 16

Bradycardia

Question 17

Fingolimod: contraindications

Answer 17

Lack of VZV immunity

Question 18

Fingolimod decreases circulating lymphoctes by ____ for up to _____ after it’s discontinued.

Answer 18

75%

2 months

Question 19

Natalizumab: class

Answer 19

Selective Adhesion-Molecule Inhibitor

Question 20

Natalizumab: MOA

Answer 20

Prevents lymphocyte migration into CNS

Question 21

Natalizumab: indication

Answer 21

Relapsing forms of MS

Question 22

Natalizumab: side efects

Answer 22

Progressive multifocal enecphalopathy

Question 23

Access of Natalizumab is restricted to whom?

Answer 23

TOUCH program participants

Question 24

Dimethyl Fumarate: class

Answer 24

Nrf2 Activator

Question 25

Dimethyl Fumarate: MOA

Answer 25

Unknown - but thought to arise from activation of anti-oxidative pathways

Question 26

Dimethyl Fumarate: indication

Answer 26

RRMS

Question 27

Dimethyl Fumarate: side effect

Answer 27

Progressive multifocal encephalopathy

Question 28

Dimethyl Fumarate: pregnancy class

Answer 28

Unknown - too new

Question 29

Dimethyl Fumarate reduces relapses by ___ per year

Answer 29

75%

Question 30

Baclofen: class

Answer 30

Antispasmotic

Question 31

Baclofen: MOA

Answer 31

GABA receptor agonist producing hyperpolarization and pre-synaptic inhibition

Question 32

Baclofen: indication

Answer 32

Muscle spasticity in MS and spinal cord lesions

Question 33

If you want to D/C Baclofen, how do you do it?

Answer 33

Down titrate slowly

Question 34

Dantrolene: class

Answer 34

Antispasmotic

Question 35

Dantrolene: MOA

Answer 35

Blocks RyR1 Ca++ channels in sarcoplasmic reticulum, esp rapid contraction fibers

Question 36

Dantrolene: indication

Answer 36

Upper motor neuron spasticity