Migraine Drugs Flashcards
Name the two Triptans
- Replax
2. Imitrex
Replax and Imitrex: MOA
Activation of trigeminal pre-synaptic serotonin receptors inhibits release of CGRP and is vasoconstricting.
Anyone know what CGRP is?
Anyone?…Anyone?…Beuller?
Replax and Imitrex: indication
Migraines with or without aura
Replax and Imitrex: side effects
Angina, serotonin syndrome
Replax and Imitrex: contraindications
Ischemic heart disease
Cerebrovascular disease
Use of an ergotamine w/in 24 hours
In what form is Replax available?
Tablet
What routes of administration are available for Imitrex?
PO, IN, SQ
Propanolol: class
Nonselective B1/B2 blocker
What is Propanolol doing on our migraine drug list?
Don’t get so worked up - it’s used for migraine Px.