Parenteral Route of Drug Administration II Flashcards
What are the drug products that are administered via IM?
- aqueous
- oil solutions
- suspensions
What are the most common areas for the intramuscular route of administration?
buttocks, thigh, deltoids
Drug administered IM are more slowly absorbed than ….
SC
What are the stages of drug absorption from IM?
- Release of drug from the dosage form
- Absorption from ICF into the blood and the lymphatic fluids
- Transport from local blood volume to general circulation
Where are SC injections delivered?
- highly vascular
- loose connective tissue
Where is the intradermal route administered?
in the corium; between epidermis and the dermis
What is an example of an intradermal route?
allergic test or TB testing
When is intra-arterial injections used?
- premature infants
- liver cancer patients
Why is the intra-arterial route rarely used?
arteries are not readily accessible and the surgery is quite risky
Drugs should be in what type of solution in oder for the formulation to be administered into this area < 10 mL?
aqueous solutions
Diluents containing what should not be used in intrathecal injections or high doses of methotrexate therapy?
preservatives
What is the purpose of delivering drugs through intraspinal injections?
allows delivery of drugs which otherwise would not cross the BBB
Which type of administration is used for anesthesia during child birth, antibiotics for meningitis, giving chemotherapy or withdrawing fluid for diagnostic purposes?
Intraspinal
Where are intraarticular injections given?
in the synovia fluid of the joint cavity of the knee
What type of solutions are administered through intraarticular injections?
suspension or aqueous solution
What is an example of a type of drug that is given through intraarticular injections?
corticosteroid