Parenteral Nutrition (part 1) Flashcards
____ ____ is the delivery of nutrients directly into the bloodstream intravenously
Parenteral nutrition
Parenteral nutrition is a means of providing adequate nutrition for those who not have sufficient ____ function to restore or maintain optimal nutrition status
GI
Indications for the use of parenteral nutrition:
-A non-functioning GI tract
-Bowel rest
-Bowel obstruction
-Bowel perforation
-High output small bowel fistula
-Enteral access is not feasible or failed trials of enteral nutrition (post-pyloric)
What could lead to a non-functioning GI tract?
-Prolonged small bowel ileus
-Severe malabsorption
-Intractable vomiting or diarrhea
-Severe short bowel syndrome
-Small bowel ischemia
-Severe IBD
What would be indications of bowel rest?
-Severe exacerbation of IBD
-Radiation enteritis
What are some contraindications to parenteral nutrition?
-Functioning GIT
-Treatment < 7 days
-Inability to obtain venous access
-Prognosis that does not warrant aggressive nutrition support
Parenteral nutrition may be used if the GIT cannot be used for over ____ days
7
Carbohydrates are in the form of ___ ___ in parenteral nutrition
Dextrose Monohydrate
Dextrose monohydrate provides ____ kcal/g
3.4
Commercially available parenteral nutrition formulas can range from ___-___% carbohydrate
5-70%
The minimum dextrose dose should be ____ mg/kg/min
1
Inadequate carbohydrate administration causes ____ to be utilized as an energy source
Protein
In stable patients, the dose of dextrose should be ___-____ mg/kg/min
4-5
We should use the low end of the dextrose range (4 mg/kg/min) for patients with…
-Diabetes mellitus
-Hyperglycemia
Critically I’ll patients should get under ____ mg/kg/min of dextrose
4
Excessive carbohydrate administration can lead to…
-Hyperglycemia
-Increased CO2 production
-Fatty liver
How to calculate the maximum carbohydrate dose:
-Decide which standard to use (4 or 5 mg/kg/min)
-(4 or 5 mg) x (weight in kg) x (1440)
-Divide value by 1000 (to convert mg to g)
What is the protein source that is added to parenteral nutrition?
Crystalline amino acids
Parenteral nutrition contains all ___ ___ ___ and some NEAA
Essential amino acids
The concentration of protein in parenteral nutrition ranges from ____-___%
3-20
The protein in parenteral nutrition provides ____ kcal/g
4
Currently, ____ is not included in crystalline amino acids solutions because it is unstable
Glutamine
Lipids in parenteral nutrition are in the form of ____ ____ ___
Lipid injectable emulsions
The source of fat is…
Long-chain fatty acid emulsion
The long-chain fatty acid emulsions in parenteral nutrition come from…
-Soybean oil
-Also contain egg yolk phospholipid and glycerol
Lipid injectable emulsions are ____-dense and ____
Calorie; isotonic
There is also a mixed oil lipid injectable emulsion called ____
Smoflipid
Smoflipid is made up of…
-30% soybean oil
-30% MCT
-25% olive oil
-15% fish oil
Another alternative lipid injectable emulsion is Omegaven, which is rich in ___-___ fatty acids
Omega 3
Omegaven is believed to have ____-____ effects
Anti-inflammatory
Omegavan is FDA-approved for use in pediatric patients with parenteral nutrition-associated _____
Cholestasis
A 10% lipid emulsion provides ____ kcal/mL or ____ kcal/g
1.1; 11
A 20% lipid emulsion provides ____ kcal/mL or ____ kcal/g
2.0; 10
A 30% lipid emulsion is only available for ____ ____ _____
Total nutrient admixture
A 30% lipid emulsion provides ____ kcal/mL or ____ kcal/g
3.0; 10
What are the minimum requirements for lipids in a parenteral nutrition formula?
-2-4% of total kcal needs from linoleic acid
-10% of total kcal needs provided as lipid in parenteral nutrition should prevent essential fatty acid deficiency
What is the optimal fat intake for someone on parenteral nutrition?
-20-30% of kcal from fat OR
-1 g/kg/day for stable patients and <1 g/kg/day for critically ill patients
Optimal fat intake reduces the complications of solely dextrose-based parenteral nutrition, such as…
-Hyperglycemia
-Respiratory compromise
Lipid injectable emulsions should be provided with a slow, continuous infusion rate over ____ or more hours per day
10
Fat overload can lead to _____
Hypertriglyceridemia
Hypertriglyceridemia can lead to…
-Impaired immune response
-Hepatic steatosis
-Acute pancreatitis
-Impaired vascular integrity
Hypertriglyceridemia can impair immune response by…
-Causing hepatic reticuloendothelial system dysfunction
-Linoleic acid inhibits cell-mediated immune response
Contraindications of lipids:
-Egg allergy
-Severe hyperlipidemia
-Use with caution in those with severe sepsis and multiple organ dysfunction syndrome
Lipid clearance is monitored by serum _____
Triglycerides
We should check baseline triglycerides prior to the initiation of ___ ____ ___, and then check again after IV lipid is initiated
Lipid injectable emulsions
We should hold IV lipids if serum triglyceride level is ____ or more mg/dL
400
If serum triglycerides continue to be 400 or more mg/dL, limit lipid injectable emulsions to ____ amount to prevent essential fatty acid deficiency
Minimal
____ is a cofactor necessary for the transport of long-chain fatty acids for beta-oxidation
Carnitine
Carnitine is not present in ___ ___
Parenteral nutrition
What populations are at risk of carnitine deficiency while on parenteral nutrition?
-Premature infants
-Dialysis patients
A deficiency of carnitine can lead to…
-Hypertriglyceridemia
-Fatty liver
-Hypoglycemia
-Muscle weakness
-Cardiomyopathy
An IV form of L-carnitine is available to treat _____
Deficiency
Vitamins are provided together in a ____ ml dose of “standard vitamins”
10
Vitamin requirements differ from the ____
DRI’s
Parenteral requirements for many vitamins are ____ for many of the vitamins due to decreased stability in parenteral nutrition
Higher
Commercially prepared parenteral nutrition has ___ mL/day of trace elements
1
Parenteral requirements for most trace elements are ____ than enteral requirements because there is 100% absorption when given IV
Lower
What is the recommended dose of zinc in parenteral nutrition?
3-5 mg/day
An additional ___ mg/day of zinc should be given to hypermetabolic patients
2
Patients with EC fistulae, diarrhea, and intestinal drainage may require up to ___-___ mg of zinc per liter of lost fluid
12-17
What is the recommended dose of copper in parenteral nutrition?
0.3-0.5 mg/day
What is the recommended dose of manganese in parenteral nutrition?
55 mcg/day
What is the recommended dose of chromium in parenteral nutrition?
10-15 mcg/day
What is the recommended dose of selenium in parenteral nutrition?
60-100 mcg/day
What minerals are not routinely included in standard trace element preparation?
-Iron
-Iodine
-Molybdenum
With cholestatic liver disease, what minerals should be omitted from parenteral nutrition?
-Copper
-Manganese
What are the available forms of sodium in parenteral nutrition?
-Phosphate
-Chloride
-Acetate
What are the available forms of potassium in parenteral nutrition?
-Phosphate
-Chloride
-Acetate
What form of calcium is given in parenteral nutrition?
Gluconate
What form of magnesium is given in parenteral nutrition?
Sulfate
We may need to increase electrolytes if someone has…
-Abnormal losses (urinary, GI, or dermal)
-Refeeding syndrome
We may need to decrease electrolytes if someone has…
-Renal failure
-Congestive heart failure
Individual electrolytes can be adjusted to correct ____
Abnormalities
Acid-base balance is usually maintained by using equal amounts of ____ and ____ (1:1 ratio)
Chloride and acetate
If someone is having metabolic acidosis, provide more ____
Acetate
If someone is having metabolic alkalosis, provide more _____
Chloride
Parenteral nutrition product ____ are a major problem in the United States
Shortages
Shortages are due to…
-Manufacturing issues
-Company closures
-Drug recalls
-Companies can’t keep up with demand
Shortages affect both ____ and ____
Macronutrients and micronutrients
The result of product shortages is serious adverse patient outcomes, leading to…
-Use of suboptimal alternatives
-Errors
-Inadequate nutrition
-Deficiencies
Strategies to manage parenteral nutrition shortages:
-Assess each patient for need for parenteral nutrition
-Use oral or enteral nutrition when possible
-Assess at an individual level the need for specific nutrients
-Prioritize patients
-Rationing: providing 50% dose of MVI or MVI 3x/week; ILE 1x/week