Parathyroid & Ca Metabolism Disorders Flashcards by Elizabeth Sager

Q

What is the normal serum Ca range

A

about 8.5 to 10.5 mg/dL

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Q

Describe the distribution of Ca in our body

A

99% in bones & 1% in ECF (free ionized Ca helps in action potentials, muscle contraction, hormone secretion, blood coag)

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Q

Which endocrine hormones regulate calcium homeostasis

A

PTH, calcitonin, calcitriol

(kidneys, small intestine, liver, bones also regulate)

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Q

Describe the relationship of serum calcium & phosphate

A

inversely proportional (controlled by Ca, PTH, calcitriol)

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Q

Describe the storage of phosphate in our body

A

Most in our bones, remainder as intracellular components of cells (membrane, DNA, RNA, ATP, ADP, lipids, inorganics)

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Q

Describe the action of PTH on serum Ca & phosphate

A

produced by parathyroid glands
- increases serum Ca & decreases serum Phos

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Q

Describe the action of Calcitriol on serum Ca & Phosphate

A

From diet, UV light, from liver/kidneys
- increases serum Ca & serum phos

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Q

Describe the relationship between PTH & Ca

A

Inversely proportionate

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Q

Describe the eitology of hypocalcemia

A

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Q

Describe the presentation of hypocalcemia

A

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Q

Describe the diagnostics for hypocalemia

A

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Q

Describe the treatment of hypocalcemia

A

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Q

Describe the etiology of hypercalcemia

A

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Q

Describe the presentation of hypercalcemia

A

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Q

Describe the diagnostics for hypercalcemia

A

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Q

Describe the treatment for hypercalcemia

A

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Q

Describe the etiology of hyperparathyroidism

A

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Q

Describe the presentation of hyperparathyroidism

A

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Q

Describe the labs of hyperparathyroidism

A

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Q

Describe the treatment of hyperparathyroidism

A

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Q

Describe the etiology of hypoparathyroidism

A

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Q

Describe the presentation of hypoparathyroidism

A

Q

Describe the labs for hypoparathyroidism

A

Q

Describe the treatment for hypoparathyroidism

A

Describe the etiology of pseudohypoparathyroidism

Describe the presentation of pseudohypoparathyroidism

Describe the labs for pseudohypoparathyroidism

Describe the treatment for pseudohypoparathyroidism

What is this called and what is it seen in

brachymetacarpals/tarsals seen in pseudohypoparathyroidism

Describe the eitology of osteoporosis

Describe the presentation of osteoporosis

Describe the diagnosis of osteoporosis

Describe the treatment of osteoporosis

Describe the screening recommendations for osteoporosis

Describe the etiology of vit D deficiency

Describe the presentation of vit D deficiency

Describe the labs for vit D deficiency

Describe the treatment for vit D deficiency

Describe the etiology of osteomalacia

Describe the presentation of osteomalacia

Describe the diagnosis of osteomalacia

Describe the treatment for osteomalacia

Describe the etiology of Rickets

Describe the presentation of rickets

Describe the diagnosis of rickets

Describe the treatment of rickets

Describe the etiology of paget's disease of the bone

Describe the presentation of paget's disease of the bone

Describe the labs for paget's disease of the bone

Describe the treatment for paget's disease of the bone

What is the most common cause of hypercalcemia

malignancy (breast, lung, renal, multiple myeloma)

Describe the etiology of malignancy & hypercalcemia

- tumor secretion of PTH related protein & production of calcitriol

Describe the evaluation of malignancy & hypercalcemia

clinical hx low/undetectable PTH, low vit D