Paraneoplastic syndromes related to cancer

Question 1

paraneoplastic cerebellar degeneration

Answer 1

seen with lung, gynecological and breast cancer

Question 2

acute new onset dizziness
nausea / vomiting, cerebellar signs
dysarthria diplophia several days later

Answer 2

paraneoplastic cerebellar degeneration

Question 3

imaging study role in paraneoplastic cerebellar degeneration

Answer 3

MRI rules out other alternate conditions

cerebellar atrophy in cerebellar folia several months after symptom onset.

Question 4

CSF with paraneoplastic cerebellar degeneration

Answer 4

mild pleocytosis and elevated protein

Question 5

paraneoplastic antibodies are:

Answer 5

anti-Yo, anti-hu anti Ri are helpful in diagnosis but negative results do not exclude the diagnosis

Question 6

anyone who presents with cerebellar degeneration

Answer 6

need to rule out underlying cancer.

Question 7

squamous cell carcinoma of the lung is associated with

Answer 7

hypercalcemia from PTH related peptide

Question 8

small cell lung cancer is related to

Answer 8

SIADH
cushings syndrome
lambert eaton syndrome

Question 9

elevated EPO (due to autonomous production of EPO)

Answer 9

• renal cell carcinoma
• rarely hepatocellular carcinoma
• cerebellar hemangioblastoma
• pheochromocytoma
• uterine myomata