Breast Cancer drugs

Question 1

overview of breast cancer drugs

Answer 1

Note some given based on status of pre or post menopause

Question 2

Aromatase inhibitors

Answer 2

Question 3

Gonadotroponin releasing hormone tx

Answer 3

Question 4

CKD4 and CK6 inhibitors - when to use them?

Answer 4

Question 5

SERMs include:

What are they contraindicated in?

Answer 5

Used in pre menopausal women

COLD VAGINA - avoid SSRI except for venlafaxine and citalopram

Question 6

Classes of chemotherapy for breast cancer

Answer 6

Chemotherapy drugs for breast cancer

Question 7

Taxanes used in breast cancer neo adjuvant chemo

Answer 7

Question 8

anthracyclines used in breast cancer when adjuvant chemo is needed

Answer 8

Question 9

alkylating agents used for adjuvant chemo in breast cancer patients

Answer 9

Question 10

What are HER2 monoclonal Ab used with HER2+ breast cancer pts?

Answer 10

Question 11

Side effects of tamoxifene

Answer 11

risk for VTE is increased 2-3x

(increased risk in 1st two years of therapy and in those who will have prolonged immobolization due to travel or surgery).

Question 12

management of someone going to get hip surgery and has been on tamoxifene for breast cancer

Answer 12

need to stop tamoxifene 2-4 weeks prior to surgery that has moderate to high risk for VTE (hip replacement)

low risk procedures for VTE don’t need to stop tamoxifene.

Question 13

when do we use tamoxifene?

Answer 13

as adjuvant endocrine therapy for non metastatic estrogen receptor positive breast cancer

• 1st line therapy for premenopausal women and can be used in post menopausal women who have intolerable side effects (joint pain) from, or contraindications to, aromatase inhibitors.