Check point inhibitors Flashcards

1
Q

adverse effects of check point inhibitors

A

hepatitis, pneumonitis, rash, colitis, arthritis, endocrine issues

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2
Q

Which cancers use check point inhibitors?

A

metastatic melanoma, NSC lung, renal cell, other advanced cancers

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3
Q

How treat autoimmune adverse reactions

A

high dose steroids

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4
Q

mutation EGFR is associated with

A

associated with metastatic adenocarcinoma of the lung

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5
Q

mutation HER2 is associated with

A

breast and metastatic gastroesophageal

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6
Q

mutation BRAF is associated with

A

metastatic melanoma

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7
Q

mutation RAS is associated with

A

metastatic colorectal

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8
Q

how to treat breast metastatic gastroesophegeal

A

may respond to trastuzumab with chemo

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9
Q

how to treat metastatic melanoma

A

may respond to tyrosine kinase inhibitor

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10
Q

how to treat metastatic adenocarcinoma of lung

A

may respond to tyrosine kinase inhibitor

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11
Q

treatment of hairy cell leukemia

A

cladribine

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12
Q

malt lymphoma treatment

A

treat for H pylori

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13
Q

GIST tumor treatment

A

surgery and imatinib X3 years

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14
Q

peripheral T cell lymphoma tx

A

CHOP

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15
Q

Diffuse Large B cell tx

A

rituxan and CHOP

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16
Q

hodgkin lymphoma tx

A

ABVD

17
Q

Burkitt lymphoma tx (starry skin on biopsy)

A

rituxan AND hyper CVAD

18
Q

mantle cell lymphoma tx

A

rituxan AND hyper CVAD

19
Q

limited cutaneous T cell NLH (mycosis fungiodes (expresses CD4) tx

A

topical steroids

20
Q

renal cancer tx

A

nephrectomy

21
Q

BRCA and advanced ovarian CA which fails three or more lines of chemo treatment

A

olaparib

22
Q

advanced CLL in young peson

A

allogenic stem cell transplant

23
Q

recurrent hodgkin that respondsto salvage chemotherapy

A

autologous stem cell transplant