Paraneoplastic Syndromes Flashcards
Acanthosis Nigricans description
Hyperpigmented velvety plaques in axilla and neck
Acanthosis Nigricans cancer association
Gastric adenocarcinoma and other visceral malignancies (but more commonly associated with obesity and insulin resistance)
Sign of Leser-Trélat description
Sudden onset of multiple seborrheic keratoses
Sign of Leser-Trélat cancer association
GI adenocarcinomas and other visceral malignancies
Hypercalcemia (1) mechanism
PTHrP
Hypercalcemia (1) cancer association
Squamous cell carcinomas of lung, head, and neck; renal, bladder, breast, and ovarian carcinomas
Hypercalcemia (2) mechanism
1,25-(OH)2 vitamin D3 (calcitriol)
Hypercalcemia (2) cancer association
Lymphoma
Cushing syndrome mechanism
ACTH
Cushing syndrome cancer association
Small cell lung cancer
Hyponatremia (SIADH) mechanism
SIADH
Hyponatremia (SIADH) cancer association
Small cell lung cancer
Polycythemia mechanism
Erythropoietin
Polycythemia cancer association
Renal cell carcinoma, hepatocellular carcinoma, hemangioblastoma, pheochromocytoma, leiomyoma
Pure red cell aplasia description
Anemia with low reticulocytes
Pure red cell aplasia cancer association
Thymoma
Good syndrome description
Hypogammaglobulinemia
Good syndrome cancer association
Thymoma
Trousseau syndrome description
Migratory super cial thrombophlebitis
Trousseau syndrome cancer association
Adenocarcinomas, especially pancreatic
Nonbacterial thrombotic (marantic) endocarditis description
Deposition of sterile platelet thrombi on heart valves
Nonbacterial thrombotic (marantic) endocarditis cancer association
Adenocarcinomas, especially pancreatic
Anti-NMDA receptor encephalitis description
Psychiatric disturbance, memory de cits, seizures, dyskinesias, autonomic instability, language dysfunction
Anti-NMDA receptor encephalitis cancer association
Ovarian teratoma
Opsoclonus-myoclonus ataxia syndrome description
“Dancing eyes, dancing feet”
Opsoclonus-myoclonus ataxia syndrome cancer association
Neuroblastoma (children), small cell lung cancer (adults)
Paraneoplastic cerebellar degeneration description
Antibodies against Hu, Yo, and Tr antigens in Purkinje cells
Paraneoplastic cerebellar degeneration cancer association
Small cell lung cancer, gynecologic and breast cancers, and Hodgkin lymphoma
Paraneoplastic encephalomyelitis description
Antibodies against Hu antigens in neurons
Paraneoplastic encephalomyelitis cancer association
Small cell lung cancer
Lambert-Eaton myasthenic syndrome description
Antibodies against presynaptic (P/Q-type) Ca2+ channels at NMJ
Lambert-Eaton myasthenic syndrome cancer association
Small cell lung cancer
Myasthenia gravis description
Antibodies against postsynaptic AChR at NMJ
Myasthenia gravis cancer association
Thymoma
