Neoplasia

Question 1

What tumor suppressor gene is dysfunctional in nearly all cancers and Li-Fraumeni syndrome?

Answer 1

p53

Question 2

What tumor suppressor gene is dysfunctional in colorectal cancer (associated with Familial Adenomatous Polyposis)

Answer 2

APC

Question 3

What tumor suppressor gene(s) are dysfunctional in Neurofibromatosis? (2 types)

Answer 3

NF1 and NF2

Question 4

What tumor suppressor gene(s) are dysfunctional in Wilms Tumor/nephroblastoma? (2 types)

Answer 4

WT1 and WT2

Question 5

What tumor suppressor gene(s) are dysfunctional in von Hippel-Lindau disease, renal cell carcinoma

Answer 5

VHL

Question 6

What oncogene is over-expressed in many breast and ovarian cancers? (2 names)

Answer 6

HER2/neu (ERBB-2)

Question 7

What oncogene is over-expressed in Chronic Myelogenous Leukemia and Acute Lymphocytic Leukemia and how is it formed?

Answer 7

BCR-ABLt(9;22)

Question 8

What oncogene is over-expressed in Burkitt Lymphoma?

Answer 8

c-myc

Question 9

What oncogene can be over-expressed in lung tumors?

Answer 9

l-myc

Question 10

What oncogene can be over-expressed in neuroblastoma?

Answer 10

n-myc

Question 11

What oncogene is over-expressed in MEN2A and 2B along with medullary thyroid cancer?

Answer 11

RET

Question 12

What oncogene is over-expressed in melanoma and non-hodgkin lymphoma?

Answer 12

BRAF

Question 13

What tumor suppressor gene(s) are dysfunctional in breast and ovarian cancer? (2 types)

Answer 13

BRCA1/BRCA2

Question 14

What oncogene is over-expressed in Gastrointestinal Stromal Tumor?

Answer 14

c-kit

Question 15

What cancer has a t(5;12) for PDGFR and what type of receptor is it?

Answer 15

Chronic Myelomonocytic LeukemiaTyrosine Kinase

Question 16

What is activated in certain carcinomas, especially lung and colon and is up-regulated in some glioblastomas?

Answer 16

EGFR

Question 17

What is significant about the KRAS gene? (2)

Answer 17

Mutation is glycine residues on codons 12 and 13Early common mutation in GI and pancreatic tumors

Question 18

t(8;14) translocation is in what cancer and what is activated?

Answer 18

Burkitt lymphoma (c-myc activation)

Question 19

t(9;22) (Philadelphia chromosome) translocation is in what cancer and what new gene product is formed?

Answer 19

CML (BCR-ABL hybrid)

Question 20

t(11;14) translocation is in what cancer and what is activated?

Answer 20

Mantle cell lymphoma (cyclin D1 activation)

Question 21

t(14;18) translocation is in what cancer and what is activated?

Answer 21

Follicular lymphoma? (BCL-2 activation)

Question 22

t(15;17) translocation is in what cancer?

Answer 22

M3 type of AML