Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

First Aid Pathology Chapter > Neoplasia > Flashcards

Neoplasia Flashcards

1
Q

What tumor suppressor gene is dysfunctional in nearly all cancers and Li-Fraumeni syndrome?

A

p53

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What tumor suppressor gene is dysfunctional in colorectal cancer (associated with Familial Adenomatous Polyposis)

A

APC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What tumor suppressor gene(s) are dysfunctional in Neurofibromatosis? (2 types)

A

NF1 and NF2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What tumor suppressor gene(s) are dysfunctional in Wilms Tumor/nephroblastoma? (2 types)

A

WT1 and WT2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What tumor suppressor gene(s) are dysfunctional in von Hippel-Lindau disease, renal cell carcinoma

A

VHL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What oncogene is over-expressed in many breast and ovarian cancers? (2 names)

A

HER2/neu (ERBB-2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What oncogene is over-expressed in Chronic Myelogenous Leukemia and Acute Lymphocytic Leukemia and how is it formed?

A

BCR-ABLt(9;22)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What oncogene is over-expressed in Burkitt Lymphoma?

A

c-myc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What oncogene can be over-expressed in lung tumors?

A

l-myc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What oncogene can be over-expressed in neuroblastoma?

A

n-myc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What oncogene is over-expressed in MEN2A and 2B along with medullary thyroid cancer?

A

RET

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What oncogene is over-expressed in melanoma and non-hodgkin lymphoma?

A

BRAF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What tumor suppressor gene(s) are dysfunctional in breast and ovarian cancer? (2 types)

A

BRCA1/BRCA2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What oncogene is over-expressed in Gastrointestinal Stromal Tumor?

A

c-kit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What cancer has a t(5;12) for PDGFR and what type of receptor is it?

A

Chronic Myelomonocytic LeukemiaTyrosine Kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is activated in certain carcinomas, especially lung and colon and is up-regulated in some glioblastomas?

A

EGFR

17
Q

What is significant about the KRAS gene? (2)

A

Mutation is glycine residues on codons 12 and 13Early common mutation in GI and pancreatic tumors

18
Q

t(8;14) translocation is in what cancer and what is activated?

A

Burkitt lymphoma (c-myc activation)

19
Q

t(9;22) (Philadelphia chromosome) translocation is in what cancer and what new gene product is formed?

A

CML (BCR-ABL hybrid)

20
Q

t(11;14) translocation is in what cancer and what is activated?

A

Mantle cell lymphoma (cyclin D1 activation)

21
Q

t(14;18) translocation is in what cancer and what is activated?

A

Follicular lymphoma? (BCL-2 activation)

22
Q

t(15;17) translocation is in what cancer?

A

M3 type of AML

First Aid Pathology Chapter (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions