Oncogenes and Tumor Suppressors Flashcards by mohit harsh | Brainscape

Q

ALK oncogene

A

Receptor tyrosine kinase

Lung adenocarcinoma

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Q

BCR-ABL oncogene

A

Tyrosine Kinase

CML, ALL

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Q

BCL-2 oncogene

A

Antiapoptotic molecule

Follicular and diffuse large B cell lymphomas

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Q

BRAF oncogene

A

Serine/threonine kinase

Melanoma, non-Hodgkin lymphoma

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Q

c-KIT oncogene

A

Cytokine receptor

Gastrointestinal stromal tumor (GIST)

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Q

c-MYC oncogene

A

Transcription factor

Burkitt lymphoma

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Q

HER2/neu (c-erbB2) oncogene

A

Tyrosine kinase

Breast and gastric carcinomas

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Q

JAK2 oncogene

A

Tyrosine kinase

Chronic myeloproliferative disorders

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Q

KRAS oncogene

A

GTPase

Colon cancer, lung cancer, pancreatic cancer

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Q

MYCL1 oncogene

A

Transcription factor

Lung tumor

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Q

MYCN oncogene

A

Transcription factor

Neuroblastoma

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Q

RET oncogene

A

Tyrosine kinase

MEN 2A and 2B, medullary thyroid cancer

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Q

APC tumor suppressor gene

A

Colorectal cancer (associated with FAP)

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Q

BRCA1/BRCA2 tumor suppressor gene

A

DNA repair protein

Breast and ovarian cancer

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Q

CDKN2A tumor suppressor gene

A

p16, blocks G1 –> S phase

Melanoma, pancreatic cancer

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Q

DCC tumor suppressor gene

A

DCC—Deleted in Colon Cancer

Colon Cancer

Q

DPC4/SMAD4 tumor suppressor gene

A

DPC - Deleted in Pancreatic Cancer

Pancreatic Cancer

Q

MEN1 tumor suppressor gene

A

Menin

MEN 1

Q

NF1 tumor suppressor gene

A

Ras GTPase activating protein (neurofibromin)

NeuroFibromatosis type 1

Q

NF2 tumor suppressor gene

A

Merlin (schwannomin) protein

NeuroFibromatosis type 2

Q

PTEN tumor suppressor gene

A

Breast cancer, prostate cancer, endometrial cancer

Q

Rb tumor suppressor gene

A

Inhibits E2F; blocks G1 –> S phase

Retinoblastoma, osteosarcoma

Q

TP53 tumor suppressor gene

A

p53, activates p21, blocks G1 –> S phase

Most human cancers, Li-Fraumeni syndrome

Q

TSC1 tumor suppressor gene

A

Hamartin protein

Tuberous sclerosis

Q

TSC2 tumor suppressor gene

A

Tubers protein

Tuberous sclerosis

Q

VHL tumor suppressor gene

A

Inhibits HIF-1a

von Hippel-Lindau disease, renal cell carcinoma

Q

WT1/WT2 tumor suppressor gene

A

Wilms Tumor (nephroblastoma)