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Principles of Disease > Paraneoplastic Syndromes > Flashcards

Paraneoplastic Syndromes Flashcards

1
Q

Small Cell Lung Cancer Pancreatic Cancer Neural Tumors Cause what paraneoplastic syndrome through what mechanism?

A

Cushings Disease ACTH

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2
Q

Lung Small Cell Carcinoma and intracranial neoplasms Cause what paraneoplastic syndrome through what mechanism?

A

SIADH ADH or ANP

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3
Q

Lung Squamous Cell Ca Breast Ca Renal Cell Ca Adult T-Cell Leuk/Lymph Cause what paraneoplastic syndrome through what mechanism?

A

Hypercalcemia PTH-related protein (PTHRP) , TGF-α, TNF, IL-1

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4
Q

Ovarian Cancer Cause what paraneoplastic syndrome through what mechanism?

A

Hypoglycemia Insulin or insulin-like substance

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5
Q

Hepatocellular ca Lung carcinoid Pancreatic ca Cause what paraneoplastic syndrome through what mechanism?

A

Carcinoid Syndrome Serotonin, bradykinin

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6
Q

Gastric ca Renal ca Cerebellar hemangioma Hepatocellular ca Cause what paraneoplastic syndrome through what mechanism?

A

Polycythemia Erythropoieitin

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7
Q

What syndrome is provoked by a lung cancer in 50-70% of cases that causes paraneoplastic production of antibodies to voltage gated calcium channels in nerve endings.

A

Lambert Eaton Syndrome

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8
Q

Clinical Scenario: Periosteal new bone at distal ends of long bones, hands, feet, and proximal phalanges Arthritis of adjacent joints Clubbing of digits Syndrome and cancer associated

A

HYPERTROPHIC OSTEOARTHROPATHY bronchogenic carcinoma

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9
Q

DISSEMINATED INTRAVASCULAR COAGULATION (DIC) cancers (2) associated

A

Acute promyelocytic leukemia, prostate cancer

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10
Q

MARANTIC endocarditis is on what valve?

A

Mitral Valve

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11
Q

What are factors that cause cancer to be hyper-coagulable state? (3)

A

Increased clotting factors Increased inflammation Increased red cells and/or platelets

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12
Q

____ is the most thrombogenic cancer

A

MUCINOUS adenocarcinoma

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13
Q

What cancer is characterized with a “Napkin ring obstruction”

A

Colon tumors

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14
Q

What is a SENTINAL LYMPH NODE?

A

First node in a regional lymphatic system receiving lymph flow from tumor

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15
Q

In HEMATOGENOUS SPREAD where does colonization typically occur and what vessels are easily penetrated?

A

Tend to rest in first capillary bed encountered veins easily penetrated than arteries

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16
Q

____ is prolonged survival of micrometastases without progression

A

DORMANCY

17
Q

Cushings Disease ACTH

A

Small Cell Lung Cancer Pancreatic Cancer Neural Tumors Cause what paraneoplastic syndrome through what mechanism?

18
Q

SIADH ADH or ANP

A

Lung Small Cell Carcinoma and intracranial neoplasms Cause what paraneoplastic syndrome through what mechanism?

19
Q

Hypercalcemia PTH-related protein (PTHRP) , TGF-α, TNF, IL-1

A

Lung Squamous Cell Ca Breast Ca Renal Cell Ca Adult T-Cell Leuk/Lymph Cause what paraneoplastic syndrome through what mechanism?

20
Q

Hypoglycemia Insulin or insulin-like substance

A

Ovarian Cancer Cause what paraneoplastic syndrome through what mechanism?

21
Q

Carcinoid Syndrome Serotonin, bradykinin

A

Hepatocellular ca Lung carcinoid Pancreatic ca Cause what paraneoplastic syndrome through what mechanism?

22
Q

Polycythemia Erythropoieitin

A

Gastric ca Renal ca Cerebellar hemangioma Hepatocellular ca Cause what paraneoplastic syndrome through what mechanism?

23
Q

Lambert Eaton Syndrome

A

What syndrome is provoked by a lung cancer in 50-70% of cases that causes paraneoplastic production of antibodies to voltage gated calcium channels in nerve endings.

24
Q

HYPERTROPHIC OSTEOARTHROPATHY bronchogenic carcinoma

A

Clinical Scenario: Periosteal new bone at distal ends of long bones, hands, feet, and proximal phalanges Arthritis of adjacent joints Clubbing of digits Syndrome and cancer associated

25
Q

Acute promyelocytic leukemia, prostate cancer

A

DISSEMINATED INTRAVASCULAR COAGULATION (DIC) cancers (2) associated

26
Q

Mitral Valve

A

MARANTIC endocarditis is on what valve?

27
Q

Increased clotting factors Increased inflammation Increased red cells and/or platelets

A

What are factors that cause cancer to be hyper-coagulable state? (3)

28
Q

MUCINOUS adenocarcinoma

A

____ is the most thrombogenic cancer

29
Q

Colon tumors

A

What cancer is characterized with a “Napkin ring obstruction”

30
Q

First node in a regional lymphatic system receiving lymph flow from tumor

A

What is a SENTINAL LYMPH NODE?

31
Q

Tend to rest in first capillary bed encountered veins easily penetrated than arteries

A

In HEMATOGENOUS SPREAD where does colonization typically occur and what vessels are easily penetrated?

32
Q

DORMANCY

A

____ is prolonged survival of micrometastases without progression

Principles of Disease (8 decks)

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