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Principles of Disease > Auto-Immune Diseases > Flashcards

Auto-Immune Diseases Flashcards

1
Q

Autoimmune Hemolytic Anemia(AIHA) auto-antibody

A

anti-RBC antibodies

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2
Q

Autoimmune Hemolytic Anemia(AIHA) clinical signs

A

RBC hemolysis

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3
Q

Autoimmune Hemolytic Anemia(AIHA) clinical test

A

Positive Direct Coombs Test

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4
Q

Pemphigus Vulgaris auto-antibody

A

anti-desmoglein (desmosomes)

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5
Q

Pemphigus Vulgaris pathogenesis

A

IgG mediated disruption of cellular adhesion on skin and mucosa

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6
Q

Pemphigus Vulgaris clinical presentation

A

blisters all over body fishnet pattern in Immunofluorescence

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7
Q

Goodpasture’s Syndrome auto-antibody

A

anti-basement membrane in glomerulus and cross-reactivity with lung alveoli

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8
Q

Goodpasture’s Syndrome pathogenesis

A

IgG mediated complement activation and Fc receptor mediated inflammation

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9
Q

Goodpasture’s Syndrome clinical presentation

A

glomerulonephritis, lung hemorrhage

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10
Q

Goodpasture’s Syndrome treatment

A

Removing the anti-GBM antibody by plasmapheresis immunosuppressant drugs

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11
Q

Acute Rheumatic Fever auto-antibody

A

Strep A antibody cross-reacts with myocardial antigen

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12
Q

Acute Rheumatic Fever pathogenesis

A

macrophage activation and inflammation

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13
Q

Acute Rheumatic Fever clinical presentation

A

myocarditis and arthritis

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14
Q

Pernicious Anemia auto-antibody

A

anti-Intrinsic Factor (Parietal Cells)

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15
Q

Pernicious Anemia Pathogenesis

A

Neutralization of Intrinsic Factor Decreased Vit B12 absorption

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16
Q

Pernicious Anemia clinical presentation

A

abnormal erythropoiesis and anemia

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17
Q

Myasthenia Gravis auto-antibody

A

anti-Acetylcholine Receptor

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18
Q

Myasthenia Gravis Pathogenesis

A

antibody inhibits ACh binding down-modulates receptors

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19
Q

Myasthenia Gravis clinical presentation

A

muscle weakness PTOSIS

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20
Q

Grave’s Disease auto-antibody auto-antibody

A

anti-TSH Receptor

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21
Q

Grave’s Disease Pathogenesis

A

antibody stimulates TSH secretion

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22
Q

Grave’s Disease clinical presentation

A

enlarged thyroid/goiter bulging eyes

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23
Q

Serum Sickness hypersensitivity type and pathogenesis (timing after exposure and mechanism)

A

Type III antibodies to foreign proteins are produced 5-10 days after exposure Immune complexes deposit in membranes complement activation leads to damage

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24
Q

Complement serum levels in Serum Sickness?

A

decrease due to activation

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25
Q

Serum Sickness presentation

A

rash fever arthritis

26
Q

Rheumatic Arthritis auto-antibody and pathogenesis

A

IgM antibody that targets IgG Fc region Rheumatoid Factor deposits in joints, causes inflammation

27
Q

SLE auto-antibody

A

anti-dsDNA

28
Q

SLE pathogenesis

A

Ag/Ab complexes damage tissues by activating complement

29
Q

SLE presentation

A

butterfly rash after sunlight exposure systemic inflammation women more affected

30
Q

Polyarteritis nodosa pathogenesis and presentation

A

Formation of immune complexes in patients with circulating hepatitis B antigen vasculitis

31
Q

anti-RBC antibodies

A

Autoimmune Hemolytic Anemia(AIHA) auto-antibody

32
Q

RBC hemolysis

A

Autoimmune Hemolytic Anemia(AIHA) clinical signs

33
Q

Positive Direct Coombs Test

A

Autoimmune Hemolytic Anemia(AIHA) clinical test

34
Q

anti-desmoglein (desmosomes)

A

Pemphigus Vulgaris auto-antibody

35
Q

IgG mediated disruption of cellular adhesion on skin and mucosa

A

Pemphigus Vulgaris pathogenesis

36
Q

blisters all over body fishnet pattern in Immunofluorescence

A

Pemphigus Vulgaris clinical presentation

37
Q

anti-basement membrane in glomerulus and cross-reactivity with lung alveoli

A

Goodpasture’s Syndrome auto-antibody

38
Q

IgG mediated complement activation and Fc receptor mediated inflammation

A

Goodpasture’s Syndrome pathogenesis

39
Q

glomerulonephritis, lung hemorrhage

A

Goodpasture’s Syndrome clinical presentation

40
Q

Removing the anti-GBM antibody by plasmapheresis immunosuppressant drugs

A

Goodpasture’s Syndrome treatment

41
Q

Strep A antibody cross-reacts with myocardial antigen

A

Acute Rheumatic Fever auto-antibody

42
Q

macrophage activation and inflammation

A

Acute Rheumatic Fever pathogenesis

43
Q

myocarditis and arthritis

A

Acute Rheumatic Fever clinical presentation

44
Q

anti-Intrinsic Factor (Parietal Cells)

A

Pernicious Anemia auto-antibody

45
Q

Neutralization of Intrinsic Factor Decreased Vit B12 absorption

A

Pernicious Anemia Pathogenesis

46
Q

abnormal erythropoiesis and anemia

A

Pernicious Anemia clinical presentation

47
Q

anti-Acetylcholine Receptor

A

Myasthenia Gravis auto-antibody

47
Q

antibody inhibits ACh binding down-modulates receptors

A

Myasthenia Gravis Pathogenesis

47
Q

muscle weakness PTOSIS

A

Myasthenia Gravis clinical presentation

47
Q

anti-TSH Receptor

A

Grave’s Disease auto-antibody auto-antibody

48
Q

antibody stimulates TSH secretion

A

Grave’s Disease Pathogenesis

48
Q

enlarged thyroid/goiter bulging eyes

A

Grave’s Disease clinical presentation

49
Q

Type III antibodies to foreign proteins are produced 5-10 days after exposure Immune complexes deposit in membranes complement activation leads to damage

A

Serum Sickness hypersensitivity type and pathogenesis (timing after exposure and mechanism)

49
Q

decrease due to activation

A

Complement serum levels in Serum Sickness?

49
Q

rash fever arthritis

A

Serum Sickness presentation

49
Q

IgM antibody that targets IgG Fc region Rheumatoid Factor deposits in joints, causes inflammation

A

Rheumatic Arthritis auto-antibody and pathogenesis

49
Q

anti-dsDNA

A

SLE auto-antibody

49
Q

Ag/Ab complexes damage tissues by activating complement

A

SLE pathogenesis

49
Q

butterfly rash after sunlight exposure systemic inflammation women more affected

A

SLE presentation

50
Q

Formation of immune complexes in patients with circulating hepatitis B antigen vasculitis

A

Polyarteritis nodosa pathogenesis and presentation

Principles of Disease (8 decks)

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