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Principles of Disease > Need to Know PoD Exam 1 > Flashcards

Need to Know PoD Exam 1 Flashcards

1
Q

Rifampin

A

binds to ß subunit of RNAP

blocks initiation of transcription

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2
Q

Streptolydigin

A

binds ß subunit of RNAP

blocks elongation of transcription

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3
Q

Actinomycin D

A

blocks holoenzyme

blocks elongation of transcription

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4
Q

streptovaricin

A

blocks initiation of transcription

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5
Q

Streptomycin and aminoglycosides

A

blocks 70S assembly

induces misreading in ribosome past initiation phase

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6
Q

Tetracyclins

A

block binding of charged tRNA to acceptor site

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7
Q

Chloramphenicol

A

blocks peptidyltransfer rxn

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8
Q

erythromyocin

A

blocks translocation step

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9
Q

Diptheria Toxin

A

AB Toxin that blocks EF2

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10
Q

Increasing Km leads to

A

decreasing binding affinity (equivelant to Kd)

decrease metabolic rate

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11
Q

decrease Vmax leads to

A

decrease enzyme present

decreases metabolic rate

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12
Q

What cytokines allow for the survival of B and T memory cells?

A

IL-7 and IL-15

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13
Q

What enzyme does class (isotope) switching

A

AID

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14
Q

What cytokine makes IgM go to IgE

A

IL-4

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15
Q

what enzyme makes IgM go to IgG

A

IFNg and TGFb

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16
Q

What cytokine makes IgM go to IgA

A

TGFb and IL-5

17
Q

What compound induces competence in lab?

A

Calcium Phosphate

18
Q

Asians have what polymorphism

A

decreased aldehyde dehydrogenase
cannot metabolism EtOH
increase peak concentration due to slower elimination
red flushing

19
Q

What causes rigidity in endospores?

A

Calcium Dipicolinate

20
Q

NAT2 polymorphism

A

acetylation inactivates a compound
increased activity in Inuit and Japs
decreased activity in jews n african whites
-> more isoniazid toxicity

21
Q

CYP 2B6 polymorphism

A

cyclophosphamide failure

anticancer drug no longer works

22
Q

CYP2C9 polymorphism

A

increased risk of bleeding with warfarin

decrease dose

23
Q

G6PD deficiency

A

if people taking dapsone (leprosy drug)

get Methemoglobinemia

24
Q

CYP1A2

A

smoking induces warfarin and acetaminophen metabolism

25
Q

CYP2E1

A

EtOH induces acetaminophen metabolism

26
Q

Two examples of zero order kinetics drugs

A

EtOH and Aspirin

Principles of Disease (8 decks)

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