Need to Know PoD Exam 1 Flashcards
Rifampin
binds to ß subunit of RNAP
blocks initiation of transcription
Streptolydigin
binds ß subunit of RNAP
blocks elongation of transcription
Actinomycin D
blocks holoenzyme
blocks elongation of transcription
streptovaricin
blocks initiation of transcription
Streptomycin and aminoglycosides
blocks 70S assembly
induces misreading in ribosome past initiation phase
Tetracyclins
block binding of charged tRNA to acceptor site
Chloramphenicol
blocks peptidyltransfer rxn
erythromyocin
blocks translocation step
Diptheria Toxin
AB Toxin that blocks EF2
Increasing Km leads to
decreasing binding affinity (equivelant to Kd)
decrease metabolic rate
decrease Vmax leads to
decrease enzyme present
decreases metabolic rate
What cytokines allow for the survival of B and T memory cells?
IL-7 and IL-15
What enzyme does class (isotope) switching
AID
What cytokine makes IgM go to IgE
IL-4
what enzyme makes IgM go to IgG
IFNg and TGFb
What cytokine makes IgM go to IgA
TGFb and IL-5
What compound induces competence in lab?
Calcium Phosphate
Asians have what polymorphism
decreased aldehyde dehydrogenase
cannot metabolism EtOH
increase peak concentration due to slower elimination
red flushing
What causes rigidity in endospores?
Calcium Dipicolinate
NAT2 polymorphism
acetylation inactivates a compound
increased activity in Inuit and Japs
decreased activity in jews n african whites
-> more isoniazid toxicity
CYP 2B6 polymorphism
cyclophosphamide failure
anticancer drug no longer works
CYP2C9 polymorphism
increased risk of bleeding with warfarin
decrease dose
G6PD deficiency
if people taking dapsone (leprosy drug)
get Methemoglobinemia
CYP1A2
smoking induces warfarin and acetaminophen metabolism
CYP2E1
EtOH induces acetaminophen metabolism
Two examples of zero order kinetics drugs
EtOH and Aspirin
